Full Product Name
TCN2 Antibody; FITC conjugated
Product Synonym Names
Transcobalamin-2; TC-2; Transcobalamin II; TC II; TCII; TCN2; TC2
Product Gene Name
anti-TCN2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P20062
Purity/Purification
>95%,Protein G purified
Immunogen
Recombinant human Transcobalamin-2 protein
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-34347 / sc-34344 / sc-34346 / sc-67119
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-TCN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TCN2 antibody
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Applications Tested/Suitable for anti-TCN2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for TCN2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000346.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000355.3
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UniProt Primary Accession #
P20062
[Other Products]
UniProt Secondary Accession #
Q96FD4; Q9BVI8; Q9UCI5; Q9UCI6; Q9UDM0[Other Products]
UniProt Related Accession #
P20062; AAB25526[Other Products]
Molecular Weight
44,421 Da
NCBI Official Full Name
transcobalamin-2 isoform 1
NCBI Official Synonym Full Names
transcobalamin 2
NCBI Official Symbol
TCN2??[Similar Products]
NCBI Official Synonym Symbols
II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750
??[Similar Products]
NCBI Protein Information
transcobalamin-2
UniProt Protein Name
Transcobalamin-2
UniProt Synonym Protein Names
Transcobalamin II; TC II; TCII
Protein Family
Transcobalamin
UniProt Gene Name
TCN2??[Similar Products]
UniProt Synonym Gene Names
TC2; TC-2; TC II; TCII??[Similar Products]
UniProt Entry Name
TCO2_HUMAN
NCBI Summary for TCN2
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for TCN2
TCN2: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency). This results in various forms of anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: endosome; extracellular region; extracellular space; lysosomal lumen
Molecular Function: cobalamin binding; metal ion binding
Biological Process: cobalamin metabolic process; cobalamin transport; cobalt ion transport; vitamin metabolic process; water-soluble vitamin metabolic process
Disease: Transcobalamin Ii Deficiency
Research Articles on TCN2
1. G and TCN2 776C>G) and transcobalamin II receptor (TCblR 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion">Transcobalamin II (TCN2 67A>G and TCN2 776C>G) and transcobalamin II receptor (TCblR 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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