Full Product Name
TCN2 (Transcobalamin 2, TC-2, Transcobalamin II, TC II, TCII, TC2)
Product Synonym Names
Anti -TCN2 (Transcobalamin 2, TC-2, Transcobalamin II, TC II, TCII, TC2)
Product Gene Name
anti-TCN2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MRHLGAFLFL LGVLGALTEM CEIPEMDSHL VEKSGQHLLP WMDRLSLEHL NPSIYVGLRL SSLQAGTKED LYLHSLKLGY QQCLLGSAFS EDDGDCQGKP SMGQLALYLL ALRANWHDHK GHPHTSYYQY GLGILALCLH QKRVHDSVVD KLLYAVEPFH QGHHSVDTAA MAGLAFTCLK RSNFNPGRRQ RITMAIRTVR EEILKAQTPE GHFGNVYSTP LALQFLMTSP MRGAELGTAC LKARVALLAS LQDGA
Chromosome Location
Chromosome: 22; NC_000022.10 (31003070..31023047). Location: 22q12.2
3D Structure
ModBase 3D Structure for Q96FD4
Specificity
Recognizes human TCN2.
Purity/Purification
Purified
Purified
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
TCN2 (AAH11239, 1-401aa) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-TCN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TCN2 antibody
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene.
Product Categories/Family for anti-TCN2 antibody
Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-TCN2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TCN2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1-5ug/ml. Detection limit for sandwich ELISA is ~1ng/ml as a capture antibody.
Western Blot: 1-5ug/ml. Using the immunogen protein lysate a specific band was detected at ~70kD.
NCBI/Uniprot data below describe general gene information for TCN2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001171655.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001184726.1
[Other Products]
UniProt Primary Accession #
Q96FD4
[Other Products]
UniProt Related Accession #
P20062; Q96FD4; AAB25526[Other Products]
Molecular Weight
44,421 Da[Similar Products]
NCBI Official Full Name
transcobalamin-2 isoform 2
NCBI Official Synonym Full Names
transcobalamin II
NCBI Official Symbol
TCN2??[Similar Products]
NCBI Official Synonym Symbols
II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750
??[Similar Products]
NCBI Protein Information
transcobalamin-2; macrocytic anemia; OTTHUMP00000199117; OTTHUMP00000199118; OTTHUMP00000199119; vitamin B12-binding protein 2; transcobalamin II; macrocytic anemia
UniProt Protein Name
TCN2 protein
Protein Family
Transcobalamin
UniProt Gene Name
TCN2??[Similar Products]
UniProt Entry Name
Q96FD4_HUMAN
NCBI Summary for TCN2
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.
UniProt Comments for TCN2
TCN2: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency). This results in various forms of anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: lysosomal lumen; extracellular space; extracellular region; endosome
Molecular Function: metal ion binding; cobalamin binding
Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process
Disease: Transcobalamin Ii Deficiency
Research Articles on TCN2
1. structural change of TCII induced by single nucleotide polymorphism
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
