Rat Tyrosyl-DNA phosphodiesterase 1 (TDP1) ELISA kit; FLJ11090; MGC104252; ; tyrosyl-DNA phosphodiesterase 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of TDP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9323364 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the tyrosyl-DNA phosphodiesterase 1 (TDP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TDP1. The ELISA analytical biochemical technique of the MBS9323364 kit is based on TDP1 antibody-TDP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TDP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TDP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

68,632 Da

tyrosyl-DNA phosphodiesterase 1

tyrosyl-DNA phosphodiesterase 1; tyr-DNA phosphodiesterase 1

Tyrosyl-DNA phosphodiesterase 1

Tyr-DNA phosphodiesterase 1??[Similar Products]

TYDP1_RAT

TDP1: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. Monomer. Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus. Belongs to the tyrosyl-DNA phosphodiesterase family.

Protein type: Phosphodiesterase; EC 3.1.4.-; DNA repair, damage

Cellular Component: cytoplasm; nucleus

Molecular Function: tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding; exonuclease activity; single-stranded DNA binding

Biological Process: single strand break repair; double-strand break repair; DNA repair

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