Product Name
Cytochrome b-245 heavy chain (CYBB), Recombinant Protein
Full Product Name
Recombinant Bovine Cytochrome b-245 heavy chain (CYBB)
Product Synonym Names
Recombinant Cytochrome b-245 heavy chain (CYBB); Cytochrome b-245 heavy chain EC= 1.-.-.-; CGD91-phox Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta Heme-binding membrane glycoprotein gp91phox Neutrophil cytochrome b 91 kDa polypeptide gp91-
Product Gene Name
CYBB recombinant protein
[Similar Products]
Product Synonym Gene Name
CYBB[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGNWVVNEGI SIFVILVWLG MNVFLFVWYY RVYDIPDKFF YTRKLLGSAL ALARAPAACL NFNCMLILLP VCRNLLSFLR GSSACCSTRI RRQLDRNLTF HKMVAWMIAL HTAIHTIAHL FNVEWCVNAR VNNSDPYSIA LSDIGDKPNE TYLNFVRQRI KNPEGGLYVA VTRLAGITGV VITLCLILII TSSTKTIRRS YFEVFWYTHH LFVIFFIGLA IHGAQRIVRG QTAESLLKHQ PRNCYQNISQ WGKIENCPIP EFSGNPPMTW KWIVGPMFLY LCERLVRFWR SQQKVVITKV VTHPFKTIEL QMKKKGFKME VGQYIFVKCP VVSKLEWHPF TLTSAPEEDF FSIHIRIVGD WTEGLFKACG CDKQEFQDAW KLPKIAVDGP FGTASEDVFS YEVVMLVGAG IGVTPFASIL KSVWYKYCNK APNLRLKKIY FYWLCRDTHA FEWFADLLQL LETQMQEKNN TDFLSYNICL TGWDESQASH FAMHHDEEKD VITGLKQKTL YGRPNWDNEF KTIGSQHPNT RIGVFLCGPE ALADTLNKQC ISNSDSGPRG VHFIFNKENF
Chromosome Location
Chromosome: X; AC_000187.1 (111079516..111112446, complement). Location: chromosome: X
3D Structure
ModBase 3D Structure for O46522
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Bos taurus (Bovine)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CYBB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CYBB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_776460.1
[Other Products]
NCBI GenBank Nucleotide #
NM_174035.4
[Other Products]
UniProt Primary Accession #
O46522
[Other Products]
UniProt Secondary Accession #
A4IF96[Other Products]
UniProt Related Accession #
O46522[Other Products]
Molecular Weight
65,643 Da[Similar Products]
NCBI Official Full Name
cytochrome b-245 heavy chain
NCBI Official Synonym Full Names
cytochrome b-245, beta polypeptide<
NCBI Official Symbol
CYBB??[Similar Products]
NCBI Official Synonym Symbols
NOX2
??[Similar Products]
NCBI Protein Information
cytochrome b-245 heavy chain; gp91-1; gp91-phox; CGD91-phox; NADPH oxidase 2; p22 phagocyte B-cytochrome; cytochrome b558 subunit beta; neutrophil cytochrome b 91 kDa polypeptide; heme-binding membrane glycoprotein gp91phox
UniProt Protein Name
Cytochrome b-245 heavy chain
UniProt Synonym Protein Names
CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; Neutrophil cytochrome b 91 kDa polypeptide; gp91-1; gp91-phox; p22 phagocyte B-cytochrome
Protein Family
Cytochrome
UniProt Gene Name
CYBB??[Similar Products]
UniProt Synonym Gene Names
Cytochrome b558 subunit beta??[Similar Products]
UniProt Entry Name
CY24B_BOVIN
UniProt Comments for CYBB
Function: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes.
Cofactor: FAD
Probable.
Subunit structure: Composed of a heavy chain (beta) and a light chain (alpha). Interacts with calprotectin (S100A8/9)
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence similarities: Contains 1 FAD-binding FR-type domain.Contains 1 ferric oxidoreductase domain.
Research Articles on CYBB
1. A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
