Mouse Homeobox protein aristaless-like 3 (ALX3) ELISA kit; MGC138212; MGC141988; aristaless-like homeobox 3; ALX homeobox 3

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ALX3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9317484 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ALX homeobox 3 (ALX3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ALX3. The ELISA analytical biochemical technique of the MBS9317484 kit is based on ALX3 antibody-ALX3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ALX3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ALX3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

36,851 Da

aristaless-like homeobox 3

homeobox protein aristaless-like 3; proline-rich transcription factor Alx3

Homeobox protein aristaless-like 3

ALX3_MOUSE

This gene belongs to Group 1 of aristaless-like genes, which are characterized by the presence of an aristaless domain and a conserved paired-like homeodomain. The encoded protein acts as a transcriptional regulator. The protein plays a role in the development of craniofacial and appendicular skeleton and may have a role in pancreatic function. [provided by RefSeq, Apr 2013]

ALX3: Transcriptional regulator with a possible role in patterning of mesoderm during development. Defects in ALX3 are the cause of frontonasal dysplasia type 1 (FND1); also called frontonasal malformation (FNM) or frontorhiny. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Belongs to the paired homeobox family.

Protein type: DNA-binding; Transcription, coactivator/corepressor

Cellular Component: nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: embryonic forelimb morphogenesis; regulation of apoptosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; pattern specification process; embryonic hindlimb morphogenesis; embryonic skeletal morphogenesis

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