Product Name
Filamin A (FLNA), Polyclonal Antibody
Full Product Name
Filamin A (Phospho-Tyr1604) Antibody
Product Synonym Names
ABP 280; ABP-280; Actin-binding protein 280; Alpha filamin; Alpha-filamin; APBX; CSBS; CVD1; Endothelial actin binding protein; Endothelial actin-binding protein; Filamin 1; Filamin A alpha; Filamin A; Filamin-1; Filamin-A; FLN; FLN-A; FLN1; FLNA; FLNA_HUMAN; FMD; MNS; NHBP; Non muscle filamin; Non-muscle filamin; OPD; OPD1; OPD2; XLVD; XMVD;
Product Gene Name
anti-FLNA antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P21333
Species Reactivity
Human, Mouse, Rat
Specificity
Phospho-Filamin A (Phospho-Tyr1604) Antibody detects endogenous levels of Filamin A only when phosphorylated at Tyr1604
Purity/Purification
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human Filamin A around the phosphorylation site of Tyr1604
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-FLNA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-FLNA antibody
Phospho-specific Ab
Applications Tested/Suitable for anti-FLNA antibody
Western Blot (WB)
Application Notes for anti-FLNA antibody
WB: 1:500-1:2000
Western Blot (WB) of anti-FLNA antibody
Western blot analysis of Phospho-Filamin A (Tyr1604) in lysates of 293, using Phospho-Filamin A (Tyr1604) Antibody(13113).
NCBI/Uniprot data below describe general gene information for FLNA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001104026.1
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NCBI GenBank Nucleotide #
NM_001110556.1
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UniProt Primary Accession #
P21333
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UniProt Secondary Accession #
Q5HY53; Q5HY55; Q8NF52; E9KL45[Other Products]
UniProt Related Accession #
P21333[Other Products]
Molecular Weight
280[Similar Products]
NCBI Official Full Name
filamin-A isoform 2
NCBI Official Synonym Full Names
filamin A
NCBI Official Symbol
FLNA??[Similar Products]
NCBI Official Synonym Symbols
FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280
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NCBI Protein Information
filamin-A
UniProt Protein Name
Filamin-A
UniProt Synonym Protein Names
Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin
UniProt Gene Name
FLNA??[Similar Products]
UniProt Synonym Gene Names
FLN; FLN1; FLN-A; ABP-280??[Similar Products]
NCBI Summary for FLNA
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
UniProt Comments for FLNA
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance ().
Research Articles on FLNA
1. Data show that AR-deficient and highly metastatic prostate cancer cell lines express higher levels of filamin A compared to normal prostate epithelial cells and AR-positive and less metastatic prostate cancer. Also, the results identified that Cao2+ via CaR-mediated signaling induces filamin A cleavage and promotes the migration in AR-deficient and highly metastatic prostate cancer cells.
Precautions
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Disclaimer
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