Full Product Name
AGAP2 Antibody
Product Gene Name
anti-AGAP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99490
Species Reactivity
Human, Rat, Mouse
Form/Format
Purified by protein A column containing 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-AGAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AGAP2 antibody
Rabbit polyclonal AGAP2 (1) antibody was raised against a peptide from C terminal residues of human AGAP2 protein.
Product Categories/Family for anti-AGAP2 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-AGAP2 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AGAP2 antibody
Peptide ELISA: 1:20,000-1:80,000
WB: 1:500-1:1,000
IHC: 1:100-1:500
Testing Data of anti-AGAP2 antibody
Testing Data of anti-AGAP2 antibody
NCBI/Uniprot data below describe general gene information for AGAP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001116244.1
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NCBI GenBank Nucleotide #
NM_001122772.2
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UniProt Primary Accession #
Q99490
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UniProt Secondary Accession #
O00578; Q548E0; Q8IWU3; A8K9F7[Other Products]
UniProt Related Accession #
Q99490[Other Products]
Molecular Weight
90,537 Da
NCBI Official Full Name
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform PIKE-L
NCBI Official Synonym Full Names
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
NCBI Official Symbol
AGAP2??[Similar Products]
NCBI Official Synonym Symbols
PIKE; GGAP2; CENTG1
??[Similar Products]
NCBI Protein Information
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
UniProt Protein Name
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
UniProt Synonym Protein Names
Centaurin-gamma-1; Cnt-g1; GTP-binding and GTPase-activating protein 2; GGAP2; Phosphatidylinositol 3-kinase enhancer; PIKE
Protein Family
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein
UniProt Gene Name
AGAP2??[Similar Products]
UniProt Synonym Gene Names
CENTG1; KIAA0167; AGAP-2; Cnt-g1; GGAP2; PIKE??[Similar Products]
NCBI Summary for AGAP2
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for AGAP2
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Product References and Citations for anti-AGAP2 antibody
(1) Shiba, Y., Romer, W., Mardones, G.A., . AGAP2 regulates retrograde transport between early endosomes and the TGN. J. Cell. Sci. 123 (PT 14), 2381-2390 (2010).
Research Articles on AGAP2
1. A pleckstrin homology domain in PIKE-L directly binds alpha-synuclein and antagonizes its aggregation. Accordingly, PIKE-L overexpression decreases dopaminergic cell death elicited by MPP(+), whereas PIKE-L knockdown elevates alpha-synuclein oligomerization and cell death.
Precautions
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Disclaimer
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