Anti-Human CD46; MCP

For Research Use Only. Not for use in diagnostic procedures.

IgG2a

169-1-E4.3

Mouse

Antibody 169-1-E4.3 recognizes the SCR1 epitope of CD46 (3).

Small volumes of anti-CD46 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Human CD46 is a cell surface glycoprotein expressed on almost all human cells except erythrocytes. CD46 is involved with regulation of complement activation and is also a measles virus receptor.

Antibodies; Conjugates

Flow Cytometry (FC/FACS), Western Blot (WB)

Antibody 169-1-E4.3 does not block MCP function (3).

44,238 Da

CD46 molecule

membrane cofactor protein

Membrane cofactor protein

MCP; MIC10??[Similar Products]

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.

1. R.L. Sparrow and I.F.C. McKenzie, (1983) Human Immunol 7: 1-15. 2. D. Christiansen, et al, (1996) Eur J Immunol 26: 578-585. 3. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 506-509.

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