Full Product Name
G6pc antibody - N-terminal region
Product Gene Name
anti-G6PC antibody
[Similar Products]
Product Synonym Gene Name
AW107337; G6Pase; G6pt; Glc-6-Pase[Similar Products]
Antibody/Peptide Pairs
G6pc peptide (MBS3232230) is used for blocking the activity of G6pc antibody (MBS3207265)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: DFGIQSTRYL QVNYQDSQDW FILVSVIADL RNAFYVLFPI WFHLKETVGI
3D Structure
ModBase 3D Structure for P35576
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 85%; Rat: 86%
Immunogen
The immunogen is a synthetic peptide corresponding to a region of Mouse
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-G6PC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-G6PC antibody
This is a rabbit polyclonal antibody against G6pc. It was validated on Western Blot
Target Description: G6pc hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. It forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
Product Categories/Family for anti-G6PC antibody
Polyclonal; Drugs and Drug Metabolism; Developmental Biology; Phosphorylation;
Applications Tested/Suitable for anti-G6PC antibody
Western Blot (WB)
Western Blot (WB) of anti-G6PC antibody
Host: Rabbit
Target Name: G6pc
Sample Tissue: Mouse Lung
Antibody Dilution: 1.0ug/ml
Western Blot (WB) of anti-G6PC antibody
Host: Rabbit
Target Name: G6PC
Sample Tissue: Mouse Mouse Liver
Antibody Dilution: 1ug/ml
Western Blot (WB) of anti-G6PC antibody
Host: Rabbit
Target Name: G6PC
Sample Tissue: Mouse Testis
Antibody Dilution: 1ug/ml
Western Blot (WB) of anti-G6PC antibody
WB Suggested Anti-G6pc Antibody
Titration: 1.0 ug/ml
Positive Control: Mouse Intestine
NCBI/Uniprot data below describe general gene information for G6PC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032087
[Other Products]
NCBI GenBank Nucleotide #
NM_008061
[Other Products]
UniProt Primary Accession #
P35576
[Other Products]
UniProt Related Accession #
P35576[Other Products]
NCBI Official Full Name
glucose-6-phosphatase
NCBI Official Synonym Full Names
glucose-6-phosphatase, catalytic
NCBI Official Symbol
G6pc??[Similar Products]
NCBI Official Synonym Symbols
G6pt; G6Pase; AW107337; Glc-6-Pase
??[Similar Products]
NCBI Protein Information
glucose-6-phosphatase
UniProt Protein Name
Glucose-6-phosphatase
Protein Family
Glucose-6-phosphatase
UniProt Gene Name
G6pc??[Similar Products]
UniProt Synonym Gene Names
G6pt; G-6-Pase; G6Pase??[Similar Products]
NCBI Summary for G6PC
The enzyme encoded by this gene is a multisubunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose. This gene is one of three glucose-6-phosphatase catalytic-subunit-encoding genes in mouse. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). [provided by RefSeq, Sep 2015]
UniProt Comments for G6PC
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
Research Articles on G6PC
1. The results reveal a previously unrecognized physiological function of NFYA in controlling glucose metabolism by up-regulating the gluconeogenic genes Pck1 and G6pc.
Precautions
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Disclaimer
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