Full Product Name
G6PC Antibody
Product Synonym Names
G6PT; GSD1; G6PC1; GSD1a; G6Pase
Product Gene Name
anti-G6PC antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P35575
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous levels of total G6PC protein.
Purity/Purification
Antigen affinity purification
Form/Format
pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
1.4 mg/mL (lot specific)
Immunogen
Synthetic peptide of human G6PC
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-G6PC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-G6PC antibody
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.
Product Categories/Family for anti-G6PC antibody
Total protein Ab
Applications Tested/Suitable for anti-G6PC antibody
Immunohistochemistry (IHC)
Application Notes for anti-G6PC antibody
IHC: 1:50-300
Immunohistochemistry (IHC) of anti-G6PC antibody
The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 47687(G6PC Antibody) at dilution 1/50.(Original magnification: 200)
NCBI/Uniprot data below describe general gene information for G6PC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000142.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000151.3
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UniProt Primary Accession #
P35575
[Other Products]
UniProt Secondary Accession #
A1L4C0; B4E1C3; K7EL82[Other Products]
UniProt Related Accession #
P35575[Other Products]
Molecular Weight
20,209 Da
NCBI Official Full Name
glucose-6-phosphatase isoform 1
NCBI Official Synonym Full Names
glucose-6-phosphatase catalytic subunit
NCBI Official Symbol
G6PC??[Similar Products]
NCBI Official Synonym Symbols
G6PT; GSD1; G6PC1; GSD1a; G6Pase
??[Similar Products]
NCBI Protein Information
glucose-6-phosphatase
UniProt Protein Name
Glucose-6-phosphatase
UniProt Synonym Protein Names
Glucose-6-phosphatase alpha; G6Pase-alpha
Protein Family
Glucose-6-phosphatase
UniProt Gene Name
G6PC??[Similar Products]
UniProt Synonym Gene Names
G6PT; G-6-Pase; G6Pase; G6Pase-alpha??[Similar Products]
NCBI Summary for G6PC
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]
UniProt Comments for G6PC
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
Research Articles on G6PC
1. Microarrays revealed that G6PC mRNA was upregulated following GDNF-mediated dopaminergic differentiation of SH-SY5Y cells. Array association analysis showed three downregulated microRNAs that could possibly influence G6PC translation. Although qRT-PCR results were not significant, they did support the microarray findings with regard to trend. Western blotting also confirmed increased G6PC protein expression following GDNF
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