Product Name
AKAP5, cDNA Clone
Full Product Name
AKAP5 cDNA Clone
Product Gene Name
AKAP5 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGGAAACCA CAATTTCAGA AATTCATGTA GAAAACAAGG ATGAGAAGAG ATCAGCAGAA GGTAGTCCTG GGGCTGAAAG GCAGAAGGAA AAGGCATCCA TGCTTTGCTT CAAGAGAAGA AAGAAAGCAG CCAAAGCACT GAAGCCCAAA GCTGGCTCTG AAGCTGCTGA TGTGGCAAGG AAGTGTCCAC AAGAAGCAGG AGCTTCTGAT CAGCCAGAGC CCACACGGGG GGCCTGGGCC TCACTCAAAC GTCTTGTAAC ACGCAGGAAA AGGTCAGAGT CTTCAAAGCA GCAAAAGCCA TTGGAGGGTG AAATGCAACC TGCAATAAAT GCTGAGGATG CTGATCTTTC TAAGAAAAAG GCAAAATCTA GACTTAAGAT TCCCTGCATA AAATTCCCAA GAGGGCCAAA AAGGAGTAAT CATTCCAAAA TTATAGAAGA CTCAGACTGC AGCATCAAAG TCCAGGAAGA AGCTGAAATT TTGGATATAC AAACACAGAC CCCATTGAAT GATCAGGCAA CAAAGGCTAA GTCAACCCAG GATCTAAGTG AAGGCATCTC ACGGAAAGAT GGTGATGAGG TCTGTGAATC AAATGTGAGC AATAGCATAA CTTCTGGAGA GAAAGTGATT TCAGTAGAAC TTGGATTAGA TAATGGGCAT TCTGCTATTC AAACGGGAAC TCTAATCCTT GAAGAAATTG AAACGATCAA GGAAAAACAA GATGTTCAAC CCCAGCAAGC AAGCCCACTT GAAACTTCAG AAACAGACCA TCAGCAGCCA GTACTTTCTG ATGTTCCTCC TTTACCTGCA ATTCCAGATC AACAAATTGT GGAAGAAGCC AGTAACAGTA CCCTAGAAAG TGCACCAAAT GGAAAAGACT ATGAAAGTAC AGAGATTGTA GCTGAAGAAA CTAAGCCAAA AGATACTGAA TTGAGCCAAG AATCAGATTT TAAAGAAAAT GGGATCACTG AAGAGAAATC CAAATCAGAA GAAAGCAAAA GAATGGAGCC AATTGCTATT ATTATTACAG ACACTGAAAT CAGTGAATTT GATGTTACAA AATCTAAAAA TGTCCCTAAG CAATTCTTAA TTTCAGCTGA AAATGAGCAA GTAGGGGTTT TTGCTAATGA TAATGGTTTT GAGGATAGAA CTTCAGAACA ATATGAAACA CTCTTAATTG AAACAGCCTC TTCTCTAGTC AAGAATGCTA TTCAGTTGTC AATAGAACAG CTGGTTAATG AAATGGCCTC TGATGATAAT AAAATAAACA ATCTTCTACA GTGA
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of AKAP5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AKAP5. It may not necessarily be applicable to this product.
NCBI Accession #
BC131516
[Other Products]
UniProt Secondary Accession #
A2RRB8[Other Products]
UniProt Related Accession #
P24588[Other Products]
Molecular Weight
47,088 Da
NCBI Official Full Name
Homo sapiens A kinase (PRKA) anchor protein 5, mRNA
NCBI Official Synonym Full Names
A-kinase anchoring protein 5
NCBI Official Symbol
AKAP5??[Similar Products]
NCBI Official Synonym Symbols
H21; AKAP75; AKAP79
??[Similar Products]
NCBI Protein Information
A-kinase anchor protein 5
UniProt Protein Name
A-kinase anchor protein 5
UniProt Synonym Protein Names
A-kinase anchor protein 79 kDa; AKAP 79; H21; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
Protein Family
A-kinase anchor protein
UniProt Gene Name
AKAP5??[Similar Products]
UniProt Synonym Gene Names
AKAP79; AKAP-5; AKAP 79??[Similar Products]
UniProt Entry Name
AKAP5_HUMAN
NCBI Summary for AKAP5
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]
UniProt Comments for AKAP5
AKAP5: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C. Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14q23.3
Cellular Component: cytosol; plasma membrane
Molecular Function: adenylate cyclase binding; protein binding; protein kinase A binding
Biological Process: positive regulation of cAMP biosynthetic process; synaptic transmission
Research Articles on AKAP5
1. Cigarette smoke-induced changes in AKAP5 and AKAP12 in patients with COPD may affect efficacy of pharmacotherapy.
Precautions
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Disclaimer
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