Product Name
SETBP1, Polyclonal Antibody
Full Product Name
SETBP1 Rabbit Polyclonal
Product Gene Name
anti-SETBP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
SET binding protein 1
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SETBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SETBP1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for SETBP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_056374.2
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NCBI GenBank Nucleotide #
NM_015559.2
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UniProt Secondary Accession #
Q6P6C3; Q9UEF3; A6H8W5[Other Products]
UniProt Related Accession #
Q9Y6X0[Other Products]
Molecular Weight
26,397 Da
NCBI Official Full Name
SET-binding protein isoform a
NCBI Official Synonym Full Names
SET binding protein 1
NCBI Official Symbol
SETBP1??[Similar Products]
NCBI Official Synonym Symbols
SEB; MRD29
??[Similar Products]
NCBI Protein Information
SET-binding protein
UniProt Protein Name
SET-binding protein
Protein Family
SET-binding protein
UniProt Gene Name
SETBP1??[Similar Products]
UniProt Synonym Gene Names
KIAA0437; SEB??[Similar Products]
UniProt Entry Name
SETBP_HUMAN
NCBI Summary for SETBP1
This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for SETBP1
SETBP1: Defects in SETBP1 are the cause of Schinzel-Giedion midface retraction syndrome (SGMFS). It is a disorder characterized by severe mental retardation, distinctive facial features, and multiple congenital malformations including skeletal abnormalities, genitourinary and renal malformations, cardiac defects, as well as a higher-than-normal prevalence of tumors, notably neuroepithelial neoplasia. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: nucleus
Molecular Function: DNA binding; protein binding
Disease: Mental Retardation, Autosomal Dominant 29; Schinzel-giedion Midface Retraction Syndrome
Research Articles on SETBP1
1. Data describe a new recurrent chromosome translocation, t(12;18)(q14-q15;q12-21), in lipomas and osteochondrolipoma resulting in HMGA2-SETBP1 fusion which suggest a close developmental relationship between the two tumor types.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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