Full Product Name
Anti-DFNA5 Antibody
Product Gene Name
anti-DFNA5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human DFNA5
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-DFNA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DFNA5 antibody
Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene.
Applications Tested/Suitable for anti-DFNA5 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DFNA5 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for DFNA5. It may not necessarily be applicable to this product.
NCBI Accession #
AAI25067.1
[Other Products]
UniProt Secondary Accession #
O14590; Q08AQ8; Q9UBV3; A4D156; B2RAX9; B3KT05[Other Products]
UniProt Related Accession #
O60443[Other Products]
Molecular Weight
36,043 Da
NCBI Official Full Name
DFNA5 protein, partial
NCBI Official Synonym Full Names
gasdermin E
NCBI Official Symbol
GSDME??[Similar Products]
NCBI Official Synonym Symbols
DFNA5; ICERE-1
??[Similar Products]
NCBI Protein Information
gasdermin-E
UniProt Protein Name
Gasdermin-E
UniProt Synonym Protein Names
Inversely correlated with estrogen receptor expression 1; ICERE-1; Non-syndromic hearing impairment protein 5
Protein Family
Non-syndromic hearing impairment protein
UniProt Gene Name
GSDME??[Similar Products]
UniProt Synonym Gene Names
GSDME-CT??[Similar Products]
NCBI Summary for DFNA5
Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DFNA5
Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (PubMed:16897187, PubMed:18223688).
Research Articles on DFNA5
1. DFNA5 methylation shows strong potential as a biomarker for detection of breast cancer. Slightly increased methylation in histologically normal breast tissue surrounding the tumor suggests that it may be a good early detection marker.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
