Product Name
SETBP1, Polyclonal Antibody
Full Product Name
SETBP1 Antibody
Product Synonym Names
SET-binding protein; SEB; SETBP1; KIAA0437
Product Gene Name
anti-SETBP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y6X0
Purity/Purification
>95%, Protein G Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunogen
Recombinant human SET-binding protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-85148
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SETBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SETBP1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for SETBP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001123582.1
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NCBI GenBank Nucleotide #
NM_001130110.1
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UniProt Primary Accession #
Q9Y6X0
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UniProt Secondary Accession #
Q6P6C3; Q9UEF3; A6H8W5[Other Products]
UniProt Related Accession #
Q9Y6X0[Other Products]
Molecular Weight
26,397 Da
NCBI Official Full Name
SET-binding protein isoform b
NCBI Official Synonym Full Names
SET binding protein 1
NCBI Official Symbol
SETBP1??[Similar Products]
NCBI Official Synonym Symbols
SEB; MRD29
??[Similar Products]
NCBI Protein Information
SET-binding protein
UniProt Protein Name
SET-binding protein
Protein Family
SET-binding protein
UniProt Gene Name
SETBP1??[Similar Products]
UniProt Synonym Gene Names
KIAA0437; SEB??[Similar Products]
UniProt Entry Name
SETBP_HUMAN
NCBI Summary for SETBP1
This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for SETBP1
SETBP1: Defects in SETBP1 are the cause of Schinzel-Giedion midface retraction syndrome (SGMFS). It is a disorder characterized by severe mental retardation, distinctive facial features, and multiple congenital malformations including skeletal abnormalities, genitourinary and renal malformations, cardiac defects, as well as a higher-than-normal prevalence of tumors, notably neuroepithelial neoplasia. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: nucleus
Molecular Function: DNA binding; protein binding
Disease: Mental Retardation, Autosomal Dominant 29; Schinzel-giedion Midface Retraction Syndrome
Research Articles on SETBP1
1. we described a patient not fulfilling the clinical criteria and showing mutation in SETBP1, we suggest that the facial gestalt associated with neurological involvement would be sufficient to indicate molecular analysis of this particular gene.
Precautions
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Disclaimer
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