Product Name
Factor XIII (F13A1), Polyclonal Antibody
Full Product Name
Sheep anti Factor XIII
Product Synonym Names
Sheep Antibody to Human Factor XIII
Product Gene Name
anti-F13A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.11 (6144311..6320924, complement). Location: 6p25.3-p24.3
3D Structure
ModBase 3D Structure for P00488
Specificity
Factor XIII
Factor XIII
Purity/Purification
Ammonium sulfate precipitation and ion exchange chromatography
Form/Format
Purified, Liquid
Concentration
9.8mg/ml (OD280nm, E^1% = 14) (lot specific)
Buffer
HEPES buffered saline, pH 7.4, 50% glycerol
Preparation and Storage
Upon receipt, store at -20 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-F13A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-F13A1 antibody
Polyclonal Antibodies to Platelets and Hemostasis Antigens
NCBI/Uniprot data below describe general gene information for F13A1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
P00488
[Other Products]
UniProt Secondary Accession #
Q59HA7; Q8N6X2; Q96P24; Q9BX29[Other Products]
UniProt Related Accession #
P00488; Q5TD18; Q9NQP5; Q9NZ69; A0A2H0[Other Products]
Molecular Weight
83,267 Da[Similar Products]
NCBI Official Full Name
factor XIII
NCBI Official Synonym Full Names
coagulation factor XIII, A1 polypeptide
NCBI Official Symbol
F13A1??[Similar Products]
NCBI Official Synonym Symbols
F13A
??[Similar Products]
NCBI Protein Information
coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase; FSF, A subunit; OTTHUMP00000015990; coagulation factor XIIIa; transglutaminase A chain; transglutaminase. plasma; fibrin stabilizing factor, A subunit; coagulation factor XIII, A polypeptide; protein-glutamine gamma-glutamyltransferase A chain; bA525O21.1 (coagulation factor XIII, A1 polypeptide)
UniProt Protein Name
Coagulation factor XIII A chain
UniProt Synonym Protein Names
Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain
Protein Family
Coagulation factor
UniProt Gene Name
F13A1??[Similar Products]
UniProt Synonym Gene Names
F13A??[Similar Products]
UniProt Entry Name
F13A_HUMAN
NCBI Summary for F13A1
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq]
UniProt Comments for F13A1
Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.
Cofactor: Binds 1 calcium ion per subunit.
Subunit structure: Tetramer of two A chains and two B chains.
Subcellular location: Cytoplasm. Secreted. Note: Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
Post-translational modification: The activation peptide is released by thrombin.
Polymorphism: There are four main allelic forms of this protein; F13A*1A, F13A*1B, F13A*2A and F13A*2B. In addition two other intermediate forms (F13A*2A and F13A*2B) seem to exist. The sequence shown is that of F13A*2B.
Involvement in disease: Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [
MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. Ref.16
Sequence similarities: Belongs to the transglutaminase superfamily. Transglutaminase family.
Sequence caution: The sequence AAA52489.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD92089.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on F13A1
1. the FXIII-A Leu34 allele may contribute to a protective effect against the development of MI. There is a low prevalence of the Leu34 allele in Han Chinese compared to Caucasians.
Precautions
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