Serine/threonine-protein kinase PINK1; mitochondrial; BRPK; PTEN-induced putative kinase protein 1; Pink1

For Research Use Only. Not for use in diagnostic procedures.

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Small volumes of Pink1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form.

63,181 Da

PTEN induced putative kinase 1

serine/threonine-protein kinase PINK1, mitochondrial

Serine/threonine-protein kinase PINK1, mitochondrial

PINK1_MOUSE

PINK1: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Interats with PARK2. Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 2.7.11.1; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; Other group; NKF2 family

Cellular Component: axon; chromatin; cytoplasm; cytoskeleton; cytosol; integral to mitochondrial outer membrane; membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial outer membrane; mitochondrial outer membrane translocase complex; mitochondrion; nucleus; perinuclear region of cytoplasm; TORC2 complex

Molecular Function: ATP binding; kinase activity; magnesium ion binding; protease binding; protein kinase activity; protein kinase B binding; protein serine/threonine kinase activity; ubiquitin protein ligase binding

Biological Process: mitochondrion degradation; mitochondrion organization and biogenesis; negative regulation of apoptosis; negative regulation of macroautophagy; negative regulation of neuron apoptosis; peptidyl-serine phosphorylation; positive regulation of catecholamine secretion; positive regulation of dopamine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macroautophagy; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid dephosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of synaptic transmission, dopaminergic; positive regulation of transcription factor activity; positive regulation of translation; protein amino acid phosphorylation; protein stabilization; protein ubiquitination; regulation of hydrogen peroxide metabolic process; regulation of mitochondrial membrane potential; regulation of neuron apoptosis; regulation of oxidative phosphorylation; regulation of protein complex assembly; regulation of protein ubiquitination; response to oxidative stress; response to stress

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