Product Name
Collagen IX alpha2 (COL9A2), Antibody
Full Product Name
Rabbit Collagen IX alpha2 Antibody
Product Synonym Names
Collagen IX a2
Product Gene Name
anti-COL9A2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (40766163..40782939, complement). Location: 1p33-p32
3D Structure
ModBase 3D Structure for Q14055
Species Reactivity
Human, mouse
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-COL9A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-COL9A2 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for COL9A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001843.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001852.3
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UniProt Primary Accession #
Q14055
[Other Products]
UniProt Secondary Accession #
B2RMP9[Other Products]
UniProt Related Accession #
Q14055[Other Products]
Molecular Weight
65,131 Da[Similar Products]
NCBI Official Full Name
collagen alpha-2(IX) chain
NCBI Official Synonym Full Names
collagen, type IX, alpha 2
NCBI Official Symbol
COL9A2??[Similar Products]
NCBI Official Synonym Symbols
MED; EDM2; STL5; DJ39G22.4
??[Similar Products]
NCBI Protein Information
collagen alpha-2(IX) chain; collagen alpha-2(IX) chain; alpha 2 type IX collagen; collagen IX, alpha-2 polypeptide
UniProt Protein Name
Collagen alpha-2(IX) chain
UniProt Gene Name
COL9A2??[Similar Products]
UniProt Entry Name
CO9A2_HUMAN
NCBI Summary for COL9A2
This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. This chain is unusual in that, unlike the other two type IX alpha chains, it contains a covalently attached glycosaminoglycan side chain. Mutations in this gene are associated with multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008]
UniProt Comments for COL9A2
COL9A2: Structural component of hyaline cartilage and vitreous of the eye. Defects in COL9A2 are the cause of multiple epiphyseal dysplasia type 2 (EDM2). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM2 inheritance is autosomal dominant. Defects in COL9A2 may be a cause of susceptibility to intervertebral disc disease (IDD); also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain. Defects in COL9A2 are the cause of Stickler syndrome type 5 (STL5). An autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. STL5 is characterized by high myopia, vitreoretinal degeneration, retinal detachment, mild to moderate sensorineural hearing loss, short stature in childhood, and absence of cleft palate and Pierre Robin sequence. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1p33-p32
Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region
Molecular Function: extracellular matrix structural constituent conferring tensile strength
Biological Process: axon guidance; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; skeletal development
Disease: Intervertebral Disc Disease; Epiphyseal Dysplasia, Multiple, 2; Stickler Syndrome, Type V
Research Articles on COL9A2
1. The NC2 domain of type IX collagen determines the chain composition but also the chain register of the triple helix.
Precautions
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