Product Name
Carbonic Anhydrase 13 (CA13), Active Protein
Full Product Name
Recombinant Human Carbonic Anhydrase 13 (CA13)
Product Synonym Names
Carbonic Anhydrase 13; Carbonate Dehydratase XIII; Carbonic Anhydrase XIII; CA-XIII; CA13
Product Gene Name
CA13 active protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-262aa; Full Length
Sequence
MSRLSWGYRE HNGPIHWKEF FPIADGDQQS PIEIKTKEVK YDSSLRPLSI KYDPSSAKII SNSGHSFNVD FDDTENKSVL RGGPLTGSYR LRQVHLHWGS ADDHGSEHIV DGVSYAAELH VVHWNSDKYP SFVEAAHEPD GLAVLGVFLQ IGEPNSQLQK ITDTLDSIKE KGKQTRFTNF DLLSLLPPSW DYWTYPGSLT VPPLLESVTW IVLKQPINIS SQQLAKFRSL LCTAEGEAAA FLVSNHRPPQ PLKGRKVRAS FH
3D Structure
ModBase 3D Structure for Q8N1Q1
Specificity
Expressed in thymus, small intestine, spleen, prostate, ovary, colon and testis.
Purity/Purification
>95% as determined by SDS-PAGE. (lot specific)
Form/Format
0.2 mum Filtered 20 mM Tris-HCl, 150 mM NaCl, pH 7.5
Tag
C-terminal 6xHis-tagged
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Biological Activity
The esterase activity is determined to be greater than 1000 pmol/min/ug
Protein Families
Alpha-Carbonic Anhydrase Family
Classification
Other Recombinant Protein
Preparation and Storage
Store at -20 degree C. For extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Active Protein Note
Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
Other Notes
Small volumes of CA13 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CA13 active protein
Relevance: Carbonic Anhydrase 13 (CA13) belongs to the carbonic anhydrase family which can catalyzes the reversible hydration recation of carbon dioxide. Carbonic anhydrases participate in many
biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA13 is a cytosolic enzyme and is widely expressed in human, such as thymus, small intestine, spleen, prostate, ovary, colon and testis, indicating that it may play a key role in several organs. CA13 is inhibited by acetazolamide.
Function: Reversible hydration of carbon dioxide.
Product Categories/Family for CA13 active protein
Cell Biology
NCBI/Uniprot data below describe general gene information for CA13. It may not necessarily be applicable to this product.
NCBI Accession #
NP_940986.1
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NCBI GenBank Nucleotide #
NM_198584.3
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UniProt Primary Accession #
Q8N1Q1
[Other Products]
UniProt Related Accession #
Q8N1Q1[Other Products]
Molecular Weight
30.51 kDa
NCBI Official Full Name
carbonic anhydrase 13
NCBI Official Synonym Full Names
carbonic anhydrase 13
NCBI Official Symbol
CA13??[Similar Products]
NCBI Official Synonym Symbols
CAXIII
??[Similar Products]
NCBI Protein Information
carbonic anhydrase 13
UniProt Protein Name
Carbonic anhydrase 13
UniProt Synonym Protein Names
Carbonate dehydratase XIII; Carbonic anhydrase XIII
Protein Family
Carbonic anhydrase
UniProt Gene Name
CA13??[Similar Products]
UniProt Synonym Gene Names
CA-XIII??[Similar Products]
UniProt Entry Name
CAH13_HUMAN
NCBI Summary for CA13
Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800.[supplied by OMIM, Mar 2008]
UniProt Comments for CA13
CA13: Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family.
Protein type: Energy Metabolism - nitrogen; EC 4.2.1.1; Lyase
Chromosomal Location of Human Ortholog: 8q21.2
Cellular Component: cytosol; myelin sheath
Molecular Function: carbonate dehydratase activity; zinc ion binding
Biological Process: bicarbonate transport; one-carbon compound metabolic process
Research Articles on CA13
1. Cytosolic carbonic anhydrase XIII may have a role in maintaining the acid-base balance in the kidney and the gastrointestinal and reproductive tracts. [review]
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
