Product Name
Activin receptor type-2B (Acvr2b), Recombinant Protein
Full Product Name
Activin receptor type-2B
Product Gene Name
Acvr2b recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
19-536aa; full length protein
Sequence
SGRGEAETRE CIYYNANWEL ERTNQSGLER CEGEQDKRLH CYASWRNSSG TIELVKKGCW LDDFNCYDRQ ECVATEENPQ VYFCCCEGNF CNERFTHLPE PGGPEVTYEP PPTAPTLLTV LAYSLLPIGG LSLIVLLAFW MYRHRKPPYG HVDIHEVRQC QRWAGRRDGC ADSFKPLPFQ DPGPPPPSPL VGLKPLQLLE IKARGRFGCV WKAQLMNDFV AVKIFPLQDK QSWQSEREIF STPGMKHENL LQFIAAEKRG SNLEVELWLI TAFHDKGSLT DYLKGNIITW NELCHVAETM SRGLSYLHED VPWCRGEGHK PSIAHRDFKS KNVLLKSDLT AVLADFGLAV RFEPGKPPGD THGQVGTRRY MAPEVLEGAI NFQRDAFLRI DMYAMGLVLW ELVSRCKAAD GPVDEYMLPF EEEIGQHPSL EELQEVVVHK KMRPTIKDHW LKHPGLAQLC VTIEECWDHD AEARLSAGCV EERVSLIRRS VNGTTSDCLV SLVTSVTNVD LLPKESSI
3D Structure
ModBase 3D Structure for P27040
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Mus musculus (Mouse)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Acvr2b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Acvr2b recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for Acvr2b recombinant protein
Transmembrane Protein
NCBI/Uniprot data below describe general gene information for Acvr2b. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001300686.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001313757.1
[Other Products]
UniProt Primary Accession #
P27040
[Other Products]
UniProt Secondary Accession #
Q3KQI1[Other Products]
UniProt Related Accession #
P27040[Other Products]
Molecular Weight
56,853 Da
NCBI Official Full Name
activin receptor type-2B isoform 2
NCBI Official Synonym Full Names
activin receptor IIB
NCBI Official Symbol
Acvr2b??[Similar Products]
NCBI Official Synonym Symbols
ActRIIB; 4930516B21Rik
??[Similar Products]
NCBI Protein Information
activin receptor type-2B
UniProt Protein Name
Activin receptor type-2B
UniProt Synonym Protein Names
Activin receptor type IIB; ACTR-IIB
Protein Family
Activin receptor
UniProt Gene Name
Acvr2b??[Similar Products]
UniProt Synonym Gene Names
ACTR-IIB??[Similar Products]
UniProt Entry Name
AVR2B_MOUSE
UniProt Comments for Acvr2b
ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.
Protein type: EC 2.7.11.30; Kinase, protein; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily
Cellular Component: cytoplasm; protein complex; receptor complex
Molecular Function: activin binding; growth factor binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transforming growth factor beta binding
Biological Process: activation of protein kinase activity; activin receptor signaling pathway; anterior/posterior pattern formation; blood vessel remodeling; BMP signaling pathway; determination of left/right symmetry; embryonic foregut morphogenesis; gastrulation with mouth forming second; heart development; insulin secretion; kidney development; lung development; lymphangiogenesis; mesoderm development; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; organ growth; palate development; pancreas development; pattern specification process; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; post-embryonic development; regulation of signal transduction; regulation of transcription, DNA-dependent; response to glucose stimulus; signal transduction; skeletal development; skeletal morphogenesis
Research Articles on Acvr2b
1. Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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