Product Name
Peripheral myelin protein 22 (Pmp22), Recombinant Protein
Full Product Name
Recombinant Rat Peripheral myelin protein 22 (Pmp22)
Product Synonym Names
Recombinant Peripheral myelin protein 22 (Pmp22); Peripheral myelin protein 22; PMP-22; Protein CD25 SR13 myelin protein Schwann cell membrane glycoprotein; SAG
Product Gene Name
Pmp22 recombinant protein
[Similar Products]
Product Synonym Gene Name
Pmp22; Cd25, Pmp-22[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MLLLLLGILF LHIAVLVLLF VSTIVSQWLV GNGHRTDLWQ NCTTSALGAV QHCYSSSVSE WLQSVQATMI LSVIFSVLSL FLFFCQLFTL TKGGRFYITG VFQILAGLCV MSAAAIYTVR HSEWHVNNDY SYGFAYILAW VAFPLALLSG IIYVILRKRE
Chromosome Location
Chromosome: 10; NC_005109.3 (49317000..49346994). Location: 10q22
3D Structure
ModBase 3D Structure for P25094
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Pmp22 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Pmp22. It may not necessarily be applicable to this product.
NCBI Accession #
NP_058733.1
[Other Products]
NCBI GenBank Nucleotide #
NM_017037.1
[Other Products]
UniProt Primary Accession #
P25094
[Other Products]
UniProt Related Accession #
P25094[Other Products]
Molecular Weight
17,946 Da[Similar Products]
NCBI Official Full Name
peripheral myelin protein 22
NCBI Official Synonym Full Names
peripheral myelin protein 22
NCBI Official Symbol
Pmp22??[Similar Products]
NCBI Official Synonym Symbols
Gas-3
??[Similar Products]
NCBI Protein Information
peripheral myelin protein 22; SAG; PMP-22; SR13 myelin protein; schwann cell membrane glycoprotein
UniProt Protein Name
Peripheral myelin protein 22
UniProt Synonym Protein Names
Protein CD25; SR13 myelin protein; Schwann cell membrane glycoprotein
Protein Family
Peripheral myelin protein
UniProt Gene Name
Pmp22??[Similar Products]
UniProt Synonym Gene Names
Cd25; Pmp-22; PMP-22; SAG??[Similar Products]
UniProt Entry Name
PMP22_RAT
NCBI Summary for Pmp22
mediates Schwann cell growth and peripheral myelin compaction; human homolog gene duplication causes Charcot-Marie-Tooth 1A (CMT1A) neuropathy [RGD, Feb 2006]
UniProt Comments for Pmp22
Function: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
Subcellular location: Cell membrane; Multi-pass membrane protein
By similarity.
Tissue specificity: Found exclusively in the peripheral nervous system. Present in both myelinating and nonmyelinating Schwann cells. Found in the tumors of Schwann cell lineage where axons are present (neurofibromas) but not where axons are absent (schwannomas). Ref.4
Developmental stage: Levels increase between embryonic day 21 (E21) and postnatal day 0 (PND0) and then gradually increase up to PND15. There is a slight increase between PND15 and *****hood. Ref.4
Induction: Strongly down-regulated in the initial phase after sciatic nerve injury.
Sequence similarities: Belongs to the PMP-22/EMP/MP20 family.
Research Articles on Pmp22
1. Enhanced PMP22 protein expression and morphological improvements coincide with the abolishment of thermal and mechanical hypersensitivity and pain alleviation after crush injury of a myelinated peripheral nerve.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
