Full Product Name
AKAP8 (A Kinase (PRKA) Anchor Protein 8, A Kinase Anchor Protein 8, AKAP95, DKFZp586B1222)
Product Synonym Names
Anti -AKAP8 (A Kinase (PRKA) Anchor Protein 8, A Kinase Anchor Protein 8, AKAP95, DKFZp586B1222)
Product Gene Name
anti-AKAP8 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (15464335..15490603, complement). Location: 19p13.1
3D Structure
ModBase 3D Structure for O43823
Specificity
Recognizes human AKAP8.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
Immunogen
Partial sequence of recombinant full-length protein to human AKAP8
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-AKAP8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-AKAP8 antibody
Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-AKAP8 antibody
Western Blot (WB)
Application Notes for anti-AKAP8 antibody
Suitable for use in Western Blotting.
Dilution: Western Blotting: 1:1000-1:2000
NCBI/Uniprot data below describe general gene information for AKAP8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005849.1
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NCBI GenBank Nucleotide #
NM_005858.3
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UniProt Primary Accession #
O43823
[Other Products]
UniProt Related Accession #
O43823; Q8NE02; Q9UG73[Other Products]
Molecular Weight
76,108 Da[Similar Products]
NCBI Official Full Name
A-kinase anchor protein 8
NCBI Official Synonym Full Names
A kinase (PRKA) anchor protein 8
NCBI Official Symbol
AKAP8??[Similar Products]
NCBI Official Synonym Symbols
AKAP-8; AKAP95; AKAP 95; AKAP-95; DKFZp586B1222
??[Similar Products]
NCBI Protein Information
A-kinase anchor protein 8; A-kinase anchor protein, 95kDa
UniProt Protein Name
A-kinase anchor protein 8
UniProt Synonym Protein Names
A-kinase anchor protein 95 kDa
Protein Family
A-kinase anchor protein
UniProt Gene Name
AKAP8??[Similar Products]
UniProt Synonym Gene Names
AKAP95??[Similar Products]
UniProt Entry Name
AKAP8_HUMAN
NCBI Summary for AKAP8
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq]
UniProt Comments for AKAP8
AKAP8: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Belongs to the AKAP95 family.
Protein type: RNA-binding; Adaptor/scaffold; Mitochondrial; Cell cycle regulation
Chromosomal Location of Human Ortholog: 19p13.1
Cellular Component: nucleoplasm; Golgi apparatus; nuclear matrix; membrane; mitochondrion; female pronucleus; condensed chromosome; nucleus
Molecular Function: zinc ion binding; double-stranded DNA binding
Biological Process: mitosis; mitotic chromosome condensation; signal transduction
Research Articles on AKAP8
1. role of AKAP95 in DNA replication by providing a scaffold for MCM2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
