Full Product Name
PINK1 Antibody
Product Gene Name
anti-PINK1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BXM7
Other Notes
Small volumes of anti-PINK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-PINK1 antibody
Western blot analysis PINK1 using A549 whole cell lysates
NCBI/Uniprot data below describe general gene information for PINK1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_115785.1
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NCBI GenBank Nucleotide #
NM_032409.2
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UniProt Primary Accession #
Q9BXM7
[Other Products]
UniProt Secondary Accession #
Q8N6T9; Q8NBU3; Q96DE4[Other Products]
UniProt Related Accession #
Q9BXM7[Other Products]
Molecular Weight
30,104 Da
NCBI Official Full Name
serine/threonine-protein kinase PINK1, mitochondrial
NCBI Official Synonym Full Names
PTEN induced putative kinase 1
NCBI Official Symbol
PINK1??[Similar Products]
NCBI Official Synonym Symbols
BRPK; PARK6
??[Similar Products]
NCBI Protein Information
serine/threonine-protein kinase PINK1, mitochondrial
UniProt Protein Name
Serine/threonine-protein kinase PINK1, mitochondrial
UniProt Synonym Protein Names
BRPK; PTEN-induced putative kinase protein 1
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
PINK1??[Similar Products]
NCBI Summary for PINK1
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]
UniProt Comments for PINK1
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 ().
Research Articles on PINK1
1. Study confirmed that common variants in PARL and PINK1 were associated with leprosy. Furthermore, PARL and PINK1 could physically interact with each other and were involved in the highly connected network formed by reported leprosy susceptibility genes
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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