Full Product Name
Stra6 Antibody BIOTIN-Conjugated
Product Synonym Names
MCOPCB8; MCOPS9; PP14296; Stimulated by retinoic acid 6 homolog; STRA6 antibody
Product Gene Name
anti-Stra6 antibody
[Similar Products]
Matching Pairs
Antibody: Stra6 (MBS544997)
Positive Control: Stra6 (MBS543290)
Antibody/Peptide Pairs
Stra6 peptide (MBS544534) is used for blocking the activity of Stra6 antibody (MBS544997)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O70491
Species Reactivity
Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.69 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within third large intra cytoplasmic loop within amino acid region 200-300 on rat Stra6 protein.
Expression
Widely expressed in the embryo. In the *****, is highly expressed in cells that compose blood-organ barriers in the brain (choroid plexus and the brain microvascular), in the eye (retinal pigment epithelium), in testis (the basal layer of the seminiferous epithelium), in the yolk sac, and in the chorioallantoic placenta (at protein level). Also detected in kidney, spleen, and female genital tract; and at lower levels in heart and lung.
Molecular Function
Receptor, Receptor activity
Subcellular Location
Cell membarane; Multi-pass membrane protein
Preparation and Storage
-20? degree C for long term storage
Other Notes
Small volumes of anti-Stra6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Stra6 antibody
BIOTIN-Conjugated Retinoic acid-responsive protein Antibody
May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity.
Applications Tested/Suitable for anti-Stra6 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-Stra6 antibody
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for Stra6. It may not necessarily be applicable to this product.
NCBI Accession #
AAC16016.1
[Other Products]
UniProt Primary Accession #
O70491
[Other Products]
UniProt Secondary Accession #
Q6DIA8[Other Products]
UniProt Related Accession #
O70491[Other Products]
Molecular Weight
73,775 Da
NCBI Official Full Name
retinoic acid-responsive protein
NCBI Official Synonym Full Names
stimulated by retinoic acid gene 6
NCBI Official Symbol
Stra6??[Similar Products]
NCBI Official Synonym Symbols
AI891933
??[Similar Products]
NCBI Protein Information
stimulated by retinoic acid gene 6 protein
UniProt Protein Name
Stimulated by retinoic acid gene 6 protein
UniProt Synonym Protein Names
Retinoic acid-responsive protein
Protein Family
Stimulated by retinoic acid gene 6 protein
UniProt Gene Name
Stra6??[Similar Products]
UniProt Entry Name
STRA6_MOUSE
UniProt Comments for Stra6
STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: integral to membrane; membrane; plasma membrane; protein complex
Molecular Function: protein binding; receptor activity; vitamin transporter activity
Biological Process: adrenal gland development; alveolus development; artery morphogenesis; blood vessel development; cognition; developmental growth; digestive tract morphogenesis; ear development; embryonic gut development; feeding behavior; female genitalia development; heart development; kidney development; learning; lung development; neuromuscular process; nose morphogenesis; positive regulation of behavior; positive regulation of JAK-STAT cascade; smooth muscle development; transport; vocal learning
Research Articles on Stra6
1. Studies indicate that STRA6 is indeed a bona fide vitamin A transporter and provide novel insights into the regulatory mechanism that governs vitamin A homeostasis in peripheral tissues.
Precautions
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Disclaimer
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