Product Name
C11orf79, Polyclonal Antibody
Full Product Name
C11orf79 Antibody
Product Synonym Names
FLJ20487
Product Gene Name
anti-C11orf79 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of C11orf79
Calculated Molecular Weight: 166aa; 20kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-C11orf79 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-C11orf79 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-C11orf79 antibody
WB: 1:200-1:1000
IHC: 1:20-1:200
Testing Data of anti-C11orf79 antibody
NCBI/Uniprot data below describe general gene information for C11orf79. It may not necessarily be applicable to this product.
NCBI Accession #
AAH02331.1
[Other Products]
UniProt Related Accession #
Q9NX18[Other Products]
Molecular Weight
19,599 Da
NCBI Official Full Name
Chromosome 11 open reading frame 79
NCBI Official Synonym Full Names
succinate dehydrogenase complex assembly factor 2
NCBI Official Symbol
SDHAF2??[Similar Products]
NCBI Official Synonym Symbols
PGL2; SDH5; C11orf79
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NCBI Protein Information
succinate dehydrogenase assembly factor 2, mitochondrial; SDH assembly factor 2; SDHAF2; hSDH5; succinate dehydrogenase subunit 5, mitochondrial
UniProt Protein Name
Succinate dehydrogenase assembly factor 2, mitochondrial
UniProt Gene Name
SDHAF2??[Similar Products]
UniProt Synonym Gene Names
;??[Similar Products]
UniProt Entry Name
SDHF2_HUMAN
NCBI Summary for C11orf79
This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.[provided by RefSeq, Jul 2010]
UniProt Comments for C11orf79
SDH5: a subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. SDH5 is required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH) complex II. SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Mutated in some cancers. Germline mutations cause hereditary paragangliomas type 2, or non-chromaffin paragangliomas type 2. Paragangliomas are rare tumors that arise from components of the neuroendocrine system.
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: protein binding
Biological Process: mitochondrial electron transport, succinate to ubiquinone; protein-FAD linkage; protein amino acid dephosphorylation
Disease: Paragangliomas 2
Research Articles on C11orf79
1. Loss of heterozygosity was found in more than 50 % of the von Hippel-Lindau-associated pheochromocytomas, and was correlated with a significant decrease (p < 0.05) in both SDHAF2 and SDHD mRNA expression, which may be suggestive of a pathogenic role.
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