Product Name
SDHAF2, Blocking Peptide
Full Product Name
SDHAF2 Peptide
Product Synonym Names
PGL2; SDH5; C11orf79; PGL2; Succinate dehydrogenase assembly factor 2; mitochondrial; Succinate dehydrogenase subunit 5; SDH assembly factor 2; succinate dehydrogenase complex
Product Gene Name
SDHAF2 blocking peptide
[Similar Products]
SDHAF2 peptide (MBS151920) is used for blocking the activity of SDHAF2 antibody (MBS151084)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NX18
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
16 amino acids near the amino terminus of human SDHAF2.
Preparation and Storage
Store SDHAF2 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of SDHAF2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for SDHAF2 blocking peptide
Blocking (BL)
Application Notes for SDHAF2 blocking peptide
SDHAF2 peptide is used for blocking the activity of SDHAF2 antibody.
Western Blot (WB) of SDHAF2 blocking peptide
Western blot analysis of SDHAF2 in rat liver tissue lysate with SDHAF2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
NCBI/Uniprot data below describe general gene information for SDHAF2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_060311
[Other Products]
NCBI GenBank Nucleotide #
NM_017841.2
[Other Products]
UniProt Primary Accession #
Q9NX18
[Other Products]
UniProt Related Accession #
Q9NX18[Other Products]
Molecular Weight
19,599 Da
NCBI Official Full Name
succinate dehydrogenase assembly factor 2, mitochondrial
NCBI Official Synonym Full Names
succinate dehydrogenase complex assembly factor 2
NCBI Official Symbol
SDHAF2??[Similar Products]
NCBI Official Synonym Symbols
PGL2; SDH5; C11orf79
??[Similar Products]
NCBI Protein Information
succinate dehydrogenase assembly factor 2, mitochondrial; hSDH5; SDHAF2; SDH assembly factor 2; succinate dehydrogenase subunit 5, mitochondrial
UniProt Protein Name
Succinate dehydrogenase assembly factor 2, mitochondrial
Protein Family
Succinate dehydrogenase assembly factor
UniProt Gene Name
SDHAF2??[Similar Products]
UniProt Synonym Gene Names
;??[Similar Products]
UniProt Entry Name
SDHF2_HUMAN
NCBI Summary for SDHAF2
This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.[provided by RefSeq, Jul 2010]
UniProt Comments for SDHAF2
SDH5: a subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. SDH5 is required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH) complex II. SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Mutated in some cancers. Germline mutations cause hereditary paragangliomas type 2, or non-chromaffin paragangliomas type 2. Paragangliomas are rare tumors that arise from components of the neuroendocrine system.
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: protein binding
Biological Process: mitochondrial electron transport, succinate to ubiquinone; protein-FAD linkage; protein amino acid dephosphorylation
Disease: Paragangliomas 2
Research Articles on SDHAF2
1. Loss of heterozygosity was found in more than 50 % of the von Hippel-Lindau-associated pheochromocytomas, and was correlated with a significant decrease (p < 0.05) in both SDHAF2 and SDHD mRNA expression, which may be suggestive of a pathogenic role.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
