Product Name
ALX3, Blocking Peptide
Full Product Name
ALX3 Peptide - C-terminal region
Product Gene Name
ALX3 blocking peptide
[Similar Products]
Product Synonym Gene Name
ALX3;[Similar Products]
ALX3 peptide (MBS3228284) is used for blocking the activity of ALX3 antibody (MBS3203314)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Synthetic peptide located within the following region: SAAHPGIYSI HGFPPTLGGH SFEPSSDGDY KSPSLVSLRV KPKEPPGLLN
3D Structure
ModBase 3D Structure for O95076
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of ALX3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ALX3 blocking peptide
This is a synthetic peptide designed for use in combination with anti-ALX3 Antibody, made
Target Description: This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors.
Product Categories/Family for ALX3 blocking peptide
Peptide
Applications Tested/Suitable for ALX3 blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for ALX3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006483
[Other Products]
NCBI GenBank Nucleotide #
NM_006492.3
[Other Products]
UniProt Primary Accession #
O95076
[Other Products]
UniProt Related Accession #
O95076[Other Products]
NCBI Official Full Name
homeobox protein aristaless-like 3
NCBI Official Synonym Full Names
ALX homeobox 3
NCBI Official Symbol
ALX3??[Similar Products]
NCBI Official Synonym Symbols
FND; FND1
??[Similar Products]
NCBI Protein Information
homeobox protein aristaless-like 3
UniProt Protein Name
Homeobox protein aristaless-like 3
UniProt Synonym Protein Names
Proline-rich transcription factor ALX3
Protein Family
Homeobox protein
UniProt Gene Name
ALX3??[Similar Products]
UniProt Entry Name
ALX3_HUMAN
NCBI Summary for ALX3
This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]
UniProt Comments for ALX3
ALX3: Transcriptional regulator with a possible role in patterning of mesoderm during development. Defects in ALX3 are the cause of frontonasal dysplasia type 1 (FND1); also called frontonasal malformation (FNM) or frontorhiny. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Belongs to the paired homeobox family.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding
Biological Process: regulation of apoptosis; embryonic forelimb morphogenesis; transcription, DNA-dependent; regulation of transcription, DNA-dependent; embryonic hindlimb morphogenesis; pattern specification process; embryonic skeletal morphogenesis
Disease: Frontonasal Dysplasia 1
Research Articles on ALX3
1. T, p.Gln202*) in the ALX3 gene resulting in frontorhiny in the family. This is the first mutation in the ALX3 gene, underlying frontorhiny, in Pakistani population.">Genome scan using 250k Nsp1 array followed by exome and Sanger sequence analysis revealed a novel homozygous nonsense variant (c.604C>T, p.Gln202*) in the ALX3 gene resulting in frontorhiny in the family. This is the first mutation in the ALX3 gene, underlying frontorhiny, in Pakistani population.
Precautions
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Disclaimer
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