Activin receptor type-2B; EC=2.7.11.30; Activin receptor type IIB; ACTR-IIB

For Research Use Only. Not for use in diagnostic procedures.

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Acvr2b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

57,857 Da

activin A receptor, type IIB

activin receptor type-2B; ACTR-IIB; activin receptor IIB; activin receptor type IIB; ActRIIB type II activin receptor B; Activine receptor 2b (transmembrane serine kinase)

Activin receptor type-2B

Actriib; ACTR-IIB??[Similar Products]

AVR2B_RAT

plays a role in reproductive physiology and endocrinology [RGD, Feb 2006]

ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.

Protein type: EC 2.7.11.30; Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; TKL group; STKR family; Type2 subfamily

Cellular Component: protein complex; cell; cytoplasm; integral to membrane; plasma membrane; receptor complex

Molecular Function: protein serine/threonine kinase activity; transforming growth factor beta binding; metal ion binding; growth factor binding; activin binding; protein serine/threonine/tyrosine kinase activity; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: heart development; regulation of signal transduction; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; pancreas development; embryonic foregut morphogenesis; lymphangiogenesis; response to glucose stimulus; mesoderm development; kidney development; skeletal development; gastrulation with mouth forming second; positive regulation of bone mineralization; pattern specification process; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; organ growth; insulin secretion; skeletal morphogenesis; sexual reproduction; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; lung development

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