Human Protein PIEZO1 (FAM38A) ELISA kit; KIAA0233; Mib; ; family with sequence similarity 38; member A

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of FAM38A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9325558 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the family with sequence similarity 38, member A (FAM38A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FAM38A. The ELISA analytical biochemical technique of the MBS9325558 kit is based on FAM38A antibody-FAM38A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FAM38A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FAM38A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

286,790 Da

piezo-type mechanosensitive ion channel component 1

piezo-type mechanosensitive ion channel component 1; family with sequence similarity 38, member A; membrane protein induced by beta-amyloid treatment

Piezo-type mechanosensitive ion channel component 1

FAM38A; KIAA0233; Mib??[Similar Products]

PIEZ1_HUMAN

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]

PIEZO1: Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. Belongs to the PIEZO family.

Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: mechanically-gated ion channel activity; cation channel activity

Biological Process: regulation of membrane potential; detection of mechanical stimulus; positive regulation of integrin activation; positive regulation of cell-cell adhesion mediated by integrin; cation transport

Disease: Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/or Perinatal Edema

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