Product Name
IL-23 receptor, Monoclonal Antibody
Popular Item
Full Product Name
Rat Anti-Mouse IL-23 receptor
Product Synonym Names
Anti-mouse Interleukin-23 Receptor (#6D34)
Product Gene Name
anti-IL-23 receptor antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000072.6 (67422932..67491855, complement). Location: 6 C1; 6
3D Structure
ModBase 3D Structure for Q8K4B4
Specificity
This antibody detects mouse IL-23R in Western blotting.
Purity/Purification
Protein A/G affinity chromatography
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of IL-23R extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Antigen
Mouse recombinant EC domain of IL-23 R
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-IL-23 receptor antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IL-23 receptor antibody
The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 R shares structural features with the IL-12 R beta 2, including an N-terminal Ig-like domain, two cytokine receptor domains and multiple glycosylation sites in the extracellular domain. IL-23 R lacks the three extracellular membrane-proximal fibronectin-type III domains present on IL-12 R beta 2.
Applications Tested/Suitable for anti-IL-23 receptor antibody
Western Blot (WB)
Application Notes for anti-IL-23 receptor antibody
1. Western blot: Yes (1:500-1000)
NCBI/Uniprot data below describe general gene information for IL-23 receptor. It may not necessarily be applicable to this product.
NCBI Accession #
NP_653131.2
[Other Products]
NCBI GenBank Nucleotide #
NM_144548.1
[Other Products]
UniProt Primary Accession #
Q8K4B4
[Other Products]
UniProt Related Accession #
Q8K4B4[Other Products]
Molecular Weight
73,453 Da
NCBI Official Full Name
interleukin-23 receptor
NCBI Official Synonym Full Names
interleukin 23 receptor
NCBI Official Symbol
Il23r??[Similar Products]
NCBI Official Synonym Symbols
IL-23R
??[Similar Products]
NCBI Protein Information
interleukin-23 receptor; IL-23 receptor
UniProt Protein Name
Interleukin-23 receptor
UniProt Gene Name
Il23r??[Similar Products]
UniProt Synonym Gene Names
IL-23 receptor; IL-23R??[Similar Products]
UniProt Entry Name
IL23R_MOUSE
UniProt Comments for IL-23 receptor
Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis
By similarity.
Subunit structure: Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3
By similarity.
Subcellular location: Cell membrane; Single-pass type I membrane protein
By similarity.
Tissue specificity: Expressed by Th1, Th2 and dendritic cells. Ref.1
Post-translational modification: Phosphorylated in response to IL23
By similarity.
Sequence similarities: Belongs to the type I cytokine receptor family. Type 2 subfamily.Contains 2 fibronectin type-III domains.
Research Articles on IL-23 receptor
1. the balance between the enhancing and inhibitory effects of gamma-delta T cells is regulated by their level of IL-23R expression.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
