Product Name
IL-23R, Monoclonal Antibody
Full Product Name
Monoclonal Antibody to IL-23R (Clone: ABM25G4)
Product Synonym Names
Interleukin-23 receptor; IL-23 receptor; IL-23R
Product Gene Name
anti-IL-23R antibody
[Similar Products]
Product Synonym Gene Name
IL23R[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5VWK5
Purity/Purification
Purified
Protein G Chromatography
Form/Format
100 ug in 200 ul PBS containing 0.05%?BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Immunogen Information
A partial length recombinant protein (a.a 250-450) of IL-23R was used as the immunogen for this antibody.
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeat freezing and thawing
Other Notes
Small volumes of anti-IL-23R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IL-23R antibody
IL-23, a member of the IL-12 cytokine family, is composed of a p40 subunit, which is shared with IL-12, and a p19 subunit, with an approximate molecular weight of 60 kDa. IL-23 is produced by activated dendritic cells and macrophages in response to microorganisms. IL-23 promotes Th17 cells producing TNF-a, IL-17, IL-6, IL-22, GM-CSF, and other novel factors, which are associated with the induction of autoimmune inflammation. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.?
Product Categories/Family for anti-IL-23R antibody
Immunology
Applications Tested/Suitable for anti-IL-23R antibody
Western Blot (WB)
Application Notes for anti-IL-23R antibody
WB: 1-2 ug/ml
Western Blot (WB) of anti-IL-23R antibody
Fig-1: Western blot analysis of IL-23R. Anti-IL-23R antibody (Clone: ABM25G4) was used at 1 ug/ml on (1) MCF-7, (2) THP1 and (3) A431 lysates.
NCBI/Uniprot data below describe general gene information for IL-23R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_653302.2
[Other Products]
NCBI GenBank Nucleotide #
NM_144701.2
[Other Products]
UniProt Primary Accession #
Q5VWK5
[Other Products]
UniProt Secondary Accession #
Q4VGP1; Q4VGP2; Q4VGP3; Q4VGP4; Q4VGP5; Q4VGP6; Q5VWK7; Q8IW84; Q8NFQ9; Q96AS1; C9JGX4[Other Products]
UniProt Related Accession #
Q5VWK5[Other Products]
Molecular Weight
25,551 Da
NCBI Official Full Name
interleukin-23 receptor
NCBI Official Synonym Full Names
interleukin 23 receptor
NCBI Official Symbol
IL23R??[Similar Products]
NCBI Protein Information
interleukin-23 receptor
UniProt Protein Name
Interleukin-23 receptor
UniProt Gene Name
IL23R??[Similar Products]
UniProt Synonym Gene Names
IL-23 receptor; IL-23R??[Similar Products]
NCBI Summary for IL-23R
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
UniProt Comments for IL-23R
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Research Articles on IL-23R
1. Data indicate that the interleukin-23 receptor (IL-23R) SNPs rs11209026, p.Arg381Gln; rs41313262 p.Val362Ile were not associated with susceptibility to inflammatory bowel disease (IBD) in Chinese Han population.
Precautions
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Disclaimer
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