Agxt; alanine-glyoxylate aminotransferase; Spat; Alanine-glyoxylate aminotransferase (Serine-pyruvate aminotransferase); Serine-pyruvate aminotransferase; angiotensin receptor 2; serine pyruvate aminotransferase precursor (AA -22 to 392); serine: pyruvate; AGXT (rat)

For Research Use Only. Not for use in diagnostic procedures.

100ug of dried peptide

Shipped at ambient temperature, store at -20 degree C

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of Agxt blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

43,399 Da

alanine-glyoxylate aminotransferase

serine--pyruvate aminotransferase; serine--pyruvate aminotransferase, mitochondrial; serine--pyruvate aminotransferase, peroxisomal

Serine--pyruvate aminotransferase, mitochondrial

Agt1; SPT; AGT??[Similar Products]

SPYA_RAT

This gene encodes alanine-glyoxylate aminotransferase, which catalyzes the interconversion of L-alanine and glyoxylate to pyruvate and glycine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The longer transcript variant includes an upstream translation start codon and a downstream translation start codon. The upstream start codon initiates the translation of the mitochondrial enzyme precursor while the downstream start codon initiates the translation of the peroxisomal enzyme (see PMID:2332438). [provided by RefSeq, Feb 2013]

AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Transferase; Mitochondrial; EC 2.6.1.44; Amino Acid Metabolism - alanine, aspartate and glutamate; Motility/polarity/chemotaxis; Amino Acid Metabolism - glycine, serine and threonine; EC 2.6.1.51

Cellular Component: mitochondrial matrix; mitochondrion; peroxisomal matrix; peroxisome

Molecular Function: alanine-glyoxylate transaminase activity; amino acid binding; catalytic activity; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity

Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; Notch signaling pathway; oxalic acid secretion; proteasomal protein catabolic process; pyruvate biosynthetic process; response to cAMP; response to glucocorticoid stimulus

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