AGXT; alanine-glyoxylate aminotransferase; AGT; AGT1; AGXT1; PH1; SPAT; SPT; TLH6; L-alanine: glyoxylate aminotransferase 1; hepatic peroxisomal alanine: glyoxylate aminotransferase; serine-pyruvate aminotransferase; serine: pyruvate aminotransferase; AGXT antibody; alanine-glyoxylate aminotransferase antibody; AGT antibody; AGT1 antibody; AGXT1 antibody; PH1 antibody; SPAT antibody; SPT antibody; TLH6 antibody; L-alanine: glyoxylate aminotransferase 1 antibody; hepatic peroxisomal alanine: glyoxylate aminotransferase antibody; serine-pyruvate aminotransferase antibody; serine: pyruvate aminotransferase antibody; AGXT / AGT

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-AGXT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Preliminary experiments gave a faint 37kDa band in Human Liver lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 43. 0kDa according to NP_000021.1. The 37kDa band was successfully blocked by incubation with the immunizing peptide.

43,010 Da

alanine-glyoxylate aminotransferase

serine--pyruvate aminotransferase

Serine--pyruvate aminotransferase

AGT1; SPAT; SPT; AGT??[Similar Products]

SPYA_HUMAN

This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]

AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Motility/polarity/chemotaxis; Transferase; Mitochondrial; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.44; Amino Acid Metabolism - glycine, serine and threonine; EC 2.6.1.51

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: mitochondrial matrix; peroxisomal matrix; peroxisome

Molecular Function: alanine-glyoxylate transaminase activity; amino acid binding; protein binding; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity

Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; Notch signaling pathway; oxalic acid secretion; proteasomal protein catabolic process; pyruvate biosynthetic process; response to cAMP; response to glucocorticoid stimulus

Disease: Hyperoxaluria, Primary, Type I

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