Full Product Name
ALR Polyclonal Antibody
Product Gene Name
anti-ALR antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P55789
Other Notes
Small volumes of anti-ALR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ALR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005253.3
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NCBI GenBank Nucleotide #
NM_005262.2
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UniProt Primary Accession #
P55789
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UniProt Secondary Accession #
Q53YM6; Q8TAH6; Q9H290; Q9UK40[Other Products]
UniProt Related Accession #
P55789[Other Products]
Molecular Weight
15,029 Da
NCBI Official Full Name
FAD-linked sulfhydryl oxidase ALR
NCBI Official Synonym Full Names
growth factor, augmenter of liver regeneration
NCBI Official Symbol
GFER??[Similar Products]
NCBI Official Synonym Symbols
ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1
??[Similar Products]
NCBI Protein Information
FAD-linked sulfhydryl oxidase ALR
UniProt Protein Name
FAD-linked sulfhydryl oxidase ALR
UniProt Synonym Protein Names
Augmenter of liver regeneration; hERV1; Hepatopoietin
Protein Family
Alanine racemase
UniProt Gene Name
GFER??[Similar Products]
UniProt Synonym Gene Names
ALR; HERV1; HPO; hERV1??[Similar Products]
NCBI Summary for ALR
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ALR
Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.
Research Articles on ALR
1. IKBKE plays a pivotal role in regulating cell proliferation, invasion and epithelial-mesenchymal transition of malignant glioma cells in vitro and in vivo by impacting on the Hippo pathway.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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