Product Name
IL-23R/IL-23 Receptor, Recombinant Protein
Full Product Name
Recombinant Mouse IL-23R/IL-23 Receptor Protein
Product Synonym Names
IL23R; Interleukin-23 receptor; Il23r; IL-23 receptor; IL-23R; interleukin 23 receptor
Product Gene Name
IL-23R recombinant protein
[Similar Products]
Product Synonym Gene Name
IL23R[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
GITSINCSGD MWVEPGEIFQ MGMNVSIYCQ EALKHCRPRN LYFYKNGFKE EFDITRINRT TARIWYKGFS EPHAYMHCTA ECPGHFQETL ICGKDISSGH PPDAPSNLTC VIYEYSGNMT CTWNTGKPTY IDTKYIVHVK SLETEEEQQY LASSYVKIST DSLQGSRKYL VWVQAVNSLG MENSQQLHVH LDDIVIPSAS IISRAETTND TVPKTIVYWK SKTMIEKVFC EMRYKTTTNQ TWSVKEFDAN FTYVQ
3D Structure
ModBase 3D Structure for Q8K4B4
Purity/Purification
> 95% by SDS-PAGE.
Form/Format
Lyophilized from a 0.2 muM filtered solution of PBS, pH 7.4
Endotoxin
< 1 EU/mug of the protein by LAL method.
Tag
Fc tag at the C-terminus
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Protein Construction
High quality, high purity and low endotoxin recombinant Recombinant Mouse IL-23R/IL-23 Receptor Protein (RP00689), tested reactivity in Mouse and has been validated in SDS-PAGE.100% guaranteed.
Preparation and Storage
Store the lyophilized protein at-20 degree C to-80 degree C for long term.
After reconstitution, the protein solution is stable at-20 degree C for 3 months, at 2-8 degree C for up to 1 week.
Other Notes
Small volumes of IL-23R recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IL-23R recombinant protein
Description: Recombinant Mouse IL-23R/IL-23 Receptor Protein is produced by human cells expression system. The target protein is expressed with sequence (Gly24-Asp372) of mouse IL-23R/IL-23 Receptor (Accession #Q8K4B4) fused with an Fc tag at the C-terminus.
Background: Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor beta 1 (IL12R beta 1) and IL12R beta 2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12R beta 1 subunit, which is shared withseveral cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphismsof the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
SDS-Page of IL-23R recombinant protein
Recombinant Human FSTL1/Follistatin-like 1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
NCBI/Uniprot data below describe general gene information for IL-23R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_653131.2
[Other Products]
NCBI GenBank Nucleotide #
NM_144548.1
[Other Products]
UniProt Primary Accession #
Q8K4B4
[Other Products]
UniProt Related Accession #
Q8K4B4[Other Products]
Molecular Weight
73,453 Da
NCBI Official Full Name
interleukin-23 receptor
NCBI Official Synonym Full Names
interleukin 23 receptor
NCBI Official Symbol
Il23r??[Similar Products]
NCBI Official Synonym Symbols
IL-23R
??[Similar Products]
NCBI Protein Information
interleukin-23 receptor
UniProt Protein Name
Interleukin-23 receptor
UniProt Gene Name
Il23r??[Similar Products]
UniProt Synonym Gene Names
IL-23 receptor; IL-23R??[Similar Products]
UniProt Comments for IL-23R
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis ().
Research Articles on IL-23R
1. Results suggest that the use of vectors carrying Soluble Interleukin-23 Receptor (sIL-23R) to block the interleukin-23/IL-23R interaction may be a new therapeutic strategy for the treatment of multiple sclerosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
