Product Name
ATP7B, Blocking Peptide
Full Product Name
ATP7B Antibody (C-term) Blocking Peptide
Product Synonym Names
Copper-transporting ATPase 2; Copper pump 2; Wilson disease-associated protein; WND/140 kDa; ATP7B; PWD; WC1; WND
Product Gene Name
ATP7B blocking peptide
[Similar Products]
Product Synonym Gene Name
PWD; WC1; WND[Similar Products]
Antibody/Peptide Pairs
ATP7B peptide (MBS9226105) is used for blocking the activity of ATP7B antibody (MBS9203464)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P35670
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human ATP7B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note: Predominantly found in the trans-Golgi network (TGN). Not redistributed to the plasma membrane in response to elevated copper levels Isoform 2: Cytoplasm
Tissue Location
Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver The cleaved form WND/140 kDa is found in liver cell lines and other tissues
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ATP7B blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ATP7B blocking peptide
Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
NCBI/Uniprot data below describe general gene information for ATP7B. It may not necessarily be applicable to this product.
NCBI Accession #
P35670.4
[Other Products]
UniProt Primary Accession #
P35670
[Other Products]
UniProt Secondary Accession #
Q16318; Q16319; Q4U3V3; Q59FJ9; Q5T7X7[Other Products]
UniProt Related Accession #
P35670[Other Products]
Molecular Weight
155,125 Da
NCBI Official Full Name
Copper-transporting ATPase 2
NCBI Official Synonym Full Names
ATPase copper transporting beta
NCBI Official Symbol
ATP7B??[Similar Products]
NCBI Official Synonym Symbols
WD; PWD; WC1; WND
??[Similar Products]
NCBI Protein Information
copper-transporting ATPase 2
UniProt Protein Name
Copper-transporting ATPase 2
UniProt Synonym Protein Names
Copper pump 2; Wilson disease-associated protein
UniProt Gene Name
ATP7B??[Similar Products]
UniProt Synonym Gene Names
PWD; WC1; WND??[Similar Products]
UniProt Entry Name
ATP7B_HUMAN
NCBI Summary for ATP7B
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-s. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008]
UniProt Comments for ATP7B
ATP7B: Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. Monomer. Interacts with COMMD1/MURR1. Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; EC 3.6.3.54
Chromosomal Location of Human Ortholog: 13q14.3
Cellular Component: basolateral plasma membrane; cytoplasmic membrane-bound vesicle; Golgi membrane; integral to plasma membrane; late endosome; membrane; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network membrane
Molecular Function: ATP binding; copper ion binding; copper-exporting ATPase activity; copper-transporting ATPase activity; protein binding
Biological Process: cellular copper ion homeostasis; copper ion import; copper ion transport; response to copper ion; sequestering of calcium ion
Disease: Wilson Disease
Research Articles on ATP7B
1. Metal-dependent movement of the first four metal-binding domains in ATP7B may be a trigger that initiates the overall catalytic cycle.
Precautions
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Disclaimer
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