Product Name
Interleukin-23 receptor (Il23r), Recombinant Protein
Full Product Name
Recombinant Mouse Interleukin-23 receptor (Il23r), partial
Product Gene Name
Il23r recombinant protein
[Similar Products]
Product Synonym Gene Name
Il23r[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
24-374
Sequence
GITSINC SGDMWVEPGE IFQMGMNVSI YCQEALKHCR PRNLYFYKNG FKEEFDITRI NRTTARIWYK GFSEPHAYMH CTAECPGHFQ ETLICGKDIS SGHPPDAPSN LTCVIYEYSG NMTCTWNTGK PTYIDTKYIV HVKSLETEEE QQYLASSYVK ISTDSLQGSR KYLVWVQAVN SLGMENSQQL HVHLDDIVIP SASIISRAET TNDTVPKTIV YWKSKTMIEK VFCEMRYKTT TNQTWSVKEF DANFTYVQQS EFYLEPDSKY VFQVRCQETG KRNWQPWSSP FVHQTSQETG KRNWQPWSSP FVHQTSQTVS QVTAKSSHEP QKMEMLSATI FRGHPASGNH QDIG
3D Structure
ModBase 3D Structure for Q8K4B4
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Il23r recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Il23r recombinant protein
This protein is a subunit of the receptor for IL23A
IL23. This protein pairs with the receptor molecule IL12RB1
IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
NCBI/Uniprot data below describe general gene information for Il23r. It may not necessarily be applicable to this product.
NCBI Accession #
NP_653131.2
[Other Products]
NCBI GenBank Nucleotide #
NM_144548.1
[Other Products]
UniProt Primary Accession #
Q8K4B4
[Other Products]
UniProt Related Accession #
Q8K4B4[Other Products]
Molecular Weight
73,453 Da
NCBI Official Full Name
interleukin-23 receptor
NCBI Official Synonym Full Names
interleukin 23 receptor
NCBI Official Symbol
Il23r??[Similar Products]
NCBI Official Synonym Symbols
IL-23R
??[Similar Products]
NCBI Protein Information
interleukin-23 receptor
UniProt Protein Name
Interleukin-23 receptor
Protein Family
Interleukin-23 receptor
UniProt Gene Name
Il23r??[Similar Products]
UniProt Synonym Gene Names
IL-23 receptor; IL-23R??[Similar Products]
UniProt Comments for Il23r
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis ().
Research Articles on Il23r
1. RBPJ binds and trans-activates the Il23r promoter and induces IL-23R expression and represses anti-inflammatory IL-10 production in Th17 cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
