Product Name
Spectrin alpha I (SPTA1), Polyclonal Antibody
Full Product Name
Anti-Spectrin alpha I Antibody
Product Synonym Names
SPTA; Spectrin alpha chain, erythrocytic 1; Erythroid alpha-spectrin
Product Gene Name
anti-SPTA1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02549
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Spectrin alpha I protein.
Purity/Purification
Purified by immunogen affinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human Spectrin alpha I
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-SPTA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SPTA1 antibody
Rabbit polyclonal antibody to Spectrin alpha I
Applications Tested/Suitable for anti-SPTA1 antibody
Western Blot (WB)
Application Notes for anti-SPTA1 antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-SPTA1 antibody
Western blot analysis of Spectrin alpha I expression in A549 (A), mouse liver (B), mouse lung (C), rat heart (D) whole cell lysates.
NCBI/Uniprot data below describe general gene information for SPTA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003117.2
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NCBI GenBank Nucleotide #
NM_003126.3
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UniProt Primary Accession #
P02549
[Other Products]
UniProt Secondary Accession #
Q15514; Q5VYL1; Q5VYL2; Q6LDY5[Other Products]
UniProt Related Accession #
P02549[Other Products]
Molecular Weight
279,674 Da
NCBI Official Full Name
spectrin alpha chain, erythrocytic 1
NCBI Official Synonym Full Names
spectrin alpha, erythrocytic 1
NCBI Official Symbol
SPTA1??[Similar Products]
NCBI Official Synonym Symbols
EL2; HPP; HS3; SPH3; SPTA
??[Similar Products]
NCBI Protein Information
spectrin alpha chain, erythrocytic 1
UniProt Protein Name
Spectrin alpha chain, erythrocytic 1
UniProt Synonym Protein Names
Erythroid alpha-spectrin
UniProt Gene Name
SPTA1??[Similar Products]
UniProt Synonym Gene Names
SPTA??[Similar Products]
NCBI Summary for SPTA1
This gene encodes a member of a family of molecular scaffold proteins that link the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms a component of the erythrocyte plasma membrane. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis-2, pyropoikilocytosis, and spherocytosis, type 3. [provided by RefSeq, Aug 2017]
UniProt Comments for SPTA1
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
Research Articles on SPTA1
1. A novel SPTA1 mutation (H54P) was identified in a case of hereditary elliptocytosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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