Product Name
Embryonic growth/differentiation factor 1 (Gdf1), Recombinant Protein
Full Product Name
Recombinant Mouse Embryonic growth/differentiation factor 1 (Gdf1)
Product Gene Name
Gdf1 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
238-357aa, Full Length of Mature Protein
Sequence
HTEPRVEVGP VGTCRTRRLH VSFREVGWHR WVIAPRGFLA NFCQGTCALP ETLRGPGGPP ALNHAVLRAL MHAAAPTPGA GSPCCVPERL SPISVLFFDN SDNVVLRHYE DMVVDECGCR
3D Structure
ModBase 3D Structure for P20863
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Gdf1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Gdf1 recombinant protein
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and ***** tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene.
NCBI/Uniprot data below describe general gene information for Gdf1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001156754.1
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NCBI GenBank Nucleotide #
NM_001163282.2
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UniProt Primary Accession #
P20863
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UniProt Secondary Accession #
Q6AXH1[Other Products]
UniProt Related Accession #
P20863[Other Products]
Molecular Weight
38,660 Da
NCBI Official Full Name
embryonic growth/differentiation factor 1
NCBI Official Synonym Full Names
growth differentiation factor 1
NCBI Official Symbol
Gdf1??[Similar Products]
NCBI Official Synonym Symbols
Gdf-1; AI385651
??[Similar Products]
NCBI Protein Information
embryonic growth/differentiation factor 1
UniProt Protein Name
Embryonic growth/differentiation factor 1
Protein Family
Embryonic growth/differentiation factor
UniProt Gene Name
Gdf1??[Similar Products]
UniProt Synonym Gene Names
Gdf-1; GDF-1??[Similar Products]
NCBI Summary for Gdf1
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is translated from a monocistronic mRNA early in development, and from a bicistronic mRNA in later stages that also encodes ceramide synthase 1. [provided by RefSeq, Jul 2016]
UniProt Comments for Gdf1
May mediate cell differentiation events during embryonic development.
Research Articles on Gdf1
1. Epigenetic silencing of GDF1 abrogates the growth-inhibitory SMAD signaling and renders proliferation advantage to gastric epithelial cells during carcinogenesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.