Full Product Name
FOG2 Antibody
Product Synonym Names
ZFPM2; DIH3; FOG2; Friend of GATA 2; Friend of GATA protein 2; FOG-2; Friend of GATA2; ZC2HC11B; ZNF89B; Zinc finger protein 89B; HFOG-2; Zinc finger protein ZFPM2
Product Gene Name
anti-FOG2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8WW38
Species Reactivity
Human, Mouse
Specificity
FOG2 Antibody detects endogenous levels of total FOG2
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human FOG2
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-FOG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-FOG2 antibody
Total protein Ab
Applications Tested/Suitable for anti-FOG2 antibody
Western Blot (WB)
Application Notes for anti-FOG2 antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-FOG2 antibody
Western blot analysis FOG2 using Jurkat whole cell lysates
NCBI/Uniprot data below describe general gene information for FOG2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036214.2
[Other Products]
NCBI GenBank Nucleotide #
NM_012082.3
[Other Products]
UniProt Primary Accession #
Q8WW38
[Other Products]
UniProt Secondary Accession #
Q32MA6; Q9NPL7; Q9NPS4; Q9UNI5[Other Products]
UniProt Related Accession #
Q8WW38[Other Products]
Molecular Weight
113,229 Da
NCBI Official Full Name
zinc finger protein ZFPM2
NCBI Official Synonym Full Names
zinc finger protein, FOG family member 2
NCBI Official Symbol
ZFPM2??[Similar Products]
NCBI Official Synonym Symbols
DIH3; FOG2; SRXY9; ZNF89B; hFOG-2; ZC2HC11B
??[Similar Products]
NCBI Protein Information
zinc finger protein ZFPM2
UniProt Protein Name
Zinc finger protein ZFPM2
UniProt Synonym Protein Names
Friend of GATA protein 2; FOG-2; Friend of GATA 2; hFOG-2; Zinc finger protein 89B; Zinc finger protein multitype 2
UniProt Gene Name
ZFPM2??[Similar Products]
UniProt Synonym Gene Names
FOG2; ZNF89B; FOG-2; Friend of GATA 2; hFOG-2??[Similar Products]
UniProt Entry Name
FOG2_HUMAN
NCBI Summary for FOG2
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]
UniProt Comments for FOG2
FOG2: Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2. Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF). TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent. Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3); a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension. Belongs to the FOG (Friend of GATA) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 8q23
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; transcription corepressor activity; transcription factor binding
Biological Process: blood coagulation; negative regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter
Disease: 46,xy Sex Reversal 9; Diaphragmatic Hernia 3; Tetralogy Of Fallot
Research Articles on FOG2
1. ZFPM2 is a glioma susceptibility gene, its genotype and expression showing associations with incidence and severity. The balancing selection acting on ZFPM2 may relate to its roles in multiple organ development or associated disease etiology.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
