Human Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) ELISA kit; C14orf58; CCT; FLJ20371; FLVCRL14q; feline leukemia virus subgroup C cellular receptor 2; feline virus subgoup C receptor 2; feline leukemia virus subgroup C cellular receptor family; member 2

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of FLVCR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9338550 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the feline leukemia virus subgroup C cellular receptor family, member 2 (FLVCR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FLVCR2. The ELISA analytical biochemical technique of the MBS9338550 kit is based on FLVCR2 antibody-FLVCR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FLVCR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FLVCR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

57,241 Da

feline leukemia virus subgroup C cellular receptor family, member 2

feline leukemia virus subgroup C receptor-related protein 2; calcium-chelate transporter

Feline leukemia virus subgroup C receptor-related protein 2

C14orf58; CCT??[Similar Products]

FLVC2_HUMAN

This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]

FLVCR2: Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism. Defects in FLVCR2 are the cause of proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH). It is a rare prenatally lethal disorder characterized by hydranencephaly, a distinctive glomerular vasculopathy in the central nervous system and retina, and diffuse ischemic lesions of the brain stem, basal ganglia, and spinal cord with calcifications. Hydranencephaly is a condition where the greater portions of the cerebral hemispheres and corpus striatum are replaced by cerebrospinal fluid and glial tissue. Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: heme transporter activity; heme binding

Biological Process: heme transport; transmembrane transport

Disease: Proliferative Vasculopathy And Hydranencephaly-hydrocephaly Syndrome

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