For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 15; NC_000015.9 (49030135..49103343, complement). Location: 15q21.1

Rabbit

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

1 mg/ml (lot specific)

Small volumes of anti-CEP152 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC), ELISA (EIA)

189,071 Da

centrosomal protein 152kDa

centrosomal protein of 152 kDa; asterless; microcephaly, primary autosomal recessive 4

Centrosomal protein of 152 kDa

KIAA0912; Cep152??[Similar Products]

CE152_HUMAN

This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Function: Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation. Ref.5 Ref.6 Ref.7

Subunit structure: Interacts (via N-terminus) with PLK4. Interacts (via C-terminus) with CENPJ (via-N-terminus). Interacts with CINP. Interacts with CEP63; this interaction recruits CEP152 to centrosomes. Ref.5 Ref.6 Ref.7 Ref.8

Subcellular location: Cytoplasm ? cytoskeleton ? centrosome. Note: Colocalizes with CEP63 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. Ref.5 Ref.7 Ref.8 Ref.9

Involvement in disease: Microcephaly, primary, 9 (MCPH9) [MIM:614852]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9Seckel syndrome 5 (SCKL5) [MIM:613823]: A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7

Sequence caution: The sequence AAH69186.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence BAA74935.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

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