Full Product Name
WFS1 Antibody
Product Gene Name
anti-WFS1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human
Predicted: Mouse, Rat
Form/Format
Purified by protein affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-WFS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-WFS1 antibody
Rabbit polyclonal WFS1 (1) antibody was raised against a recombinate human WFS1 protein 76-282aa (BC030130).
Applications Tested/Suitable for anti-WFS1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-WFS1 antibody
ELISA: 1:20,000-1:80,000
WB: 1:200-1:1,000
Testing Data of anti-WFS1 antibody
NCBI/Uniprot data below describe general gene information for WFS1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH30130.1
[Other Products]
UniProt Secondary Accession #
Q8N6I3; Q9UNW6; B2R797; D3DVT1[Other Products]
UniProt Related Accession #
O76024[Other Products]
Molecular Weight
100,292 Da
NCBI Official Full Name
WFS1 protein
NCBI Official Synonym Full Names
wolframin ER transmembrane glycoprotein
NCBI Official Symbol
WFS1??[Similar Products]
NCBI Official Synonym Symbols
WFS; WFRS; WFSL; CTRCT41
??[Similar Products]
NCBI Protein Information
wolframin
UniProt Protein Name
Wolframin
UniProt Gene Name
WFS1??[Similar Products]
NCBI Summary for WFS1
This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for WFS1
Participates in the regulation of cellular Ca2+ homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca2+ store.
Product References and Citations for anti-WFS1 antibody
(1) Long, J., Edwards, T., Signorello, L.B., et al. Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans. Am. J. Epidemiol. 176 (11), 995-1001 (2012).
Research Articles on WFS1
1. We show for the first time the role of WFS1 in CAO and document a statistically significant interaction between increasing cumulative cisplatin dose and rs62283056 genotype. Our clinical translational results demonstrate that pretherapy patient genotyping to minimize ototoxicity could be useful when deciding between cisplatin-based chemotherapy regimens of comparable efficacy with different cumulative doses
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
