Product Name
Connexin-32 (GJB1), Polyclonal Antibody
Full Product Name
Connexin-32 Polyclonal Antibody
Product Gene Name
anti-GJB1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08034
Other Notes
Small volumes of anti-GJB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GJB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000157.1
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NCBI GenBank Nucleotide #
NM_000166.5
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UniProt Primary Accession #
P08034
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UniProt Secondary Accession #
Q5U0S4; B2R8R2; D3DVV2[Other Products]
UniProt Related Accession #
P08034[Other Products]
Molecular Weight
32,025 Da[Similar Products]
NCBI Official Full Name
gap junction beta-1 protein
NCBI Official Synonym Full Names
gap junction protein beta 1
NCBI Official Symbol
GJB1??[Similar Products]
NCBI Official Synonym Symbols
CMTX; CX32; CMTX1
??[Similar Products]
NCBI Protein Information
gap junction beta-1 protein
UniProt Protein Name
Gap junction beta-1 protein
UniProt Synonym Protein Names
Connexin-32; Cx32; GAP junction 28 kDa liver protein
Protein Family
Gap junction beta-1 protein
UniProt Gene Name
GJB1??[Similar Products]
UniProt Synonym Gene Names
CX32; Cx32??[Similar Products]
NCBI Summary for GJB1
This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for GJB1
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Research Articles on GJB1
1. Genetic analysis revealed a total of 43 mutations including 6 novel mutations. Ten mutations were found from two or more unrelated families. p.V95M was most frequently observed. The frequency of CMTX1 was 9.6% of total Korean CMT family and was 14.8% when calculated within genetically identified cases
Precautions
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Disclaimer
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