Product Name
Connexin-32 (CX32), Polyclonal Antibody
Full Product Name
Connexin-32 Antibody
Product Synonym Names
Gap junction beta-1 protein; Connexin-32; Cx32; GAP junction 28 kDa liver protein; GJB1
Product Gene Name
anti-CX32 antibody
[Similar Products]
Product Synonym Gene Name
GJB1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08034
Species Reactivity
Human, Mouse, Rat
Specificity
Connexin-32 antibody detects endogenous levels of Connexin-32.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human Connexin-32.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-CX32 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CX32 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-CX32 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
Western Blot (WB) of anti-CX32 antibody
Western blot analysis of lysate from LOVO cells, using Connexin-32 antibody.
Immunohistochemistry (IHC) of anti-CX32 antibody
Immunohistochemistry analysis of Connexin-32 antibody in paraffin-embedded human lung carcinoma tissue.
NCBI/Uniprot data below describe general gene information for CX32. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000157.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000166.5
[Other Products]
UniProt Primary Accession #
P08034
[Other Products]
UniProt Secondary Accession #
Q5U0S4; B2R8R2; D3DVV2[Other Products]
UniProt Related Accession #
P08034[Other Products]
NCBI Official Full Name
gap junction beta-1 protein
NCBI Official Synonym Full Names
gap junction protein beta 1
NCBI Official Symbol
GJB1??[Similar Products]
NCBI Official Synonym Symbols
CMTX; CX32; CMTX1
??[Similar Products]
NCBI Protein Information
gap junction beta-1 protein
UniProt Protein Name
Gap junction beta-1 protein
UniProt Synonym Protein Names
Connexin-32; Cx32; GAP junction 28 kDa liver protein
UniProt Gene Name
GJB1??[Similar Products]
UniProt Synonym Gene Names
CX32; Cx32??[Similar Products]
NCBI Summary for CX32
This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for CX32
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Research Articles on CX32
1. Study reports mutation frequency of GJB1 in 210 Hungarian Charcot-Marie-Tooth neuropathy (CMT) patients and phenotype comparison between male and female CMT X type 1 patients. 13 missense substitutions were found in GJB1; pathogenic alterations were found mainly in males. Statistical analysis of CMT X type 1 patients revealed a significant difference between genders regarding the age of onset, CMT and examination scores.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
