Product Name
WFS1, cDNA Clone
Full Product Name
WFS1 cDNA Clone
Product Gene Name
WFS1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggactcca acactgctcc gctgggcccc tcctgcccac agcccccgcc agcaccgcag ccccaggcgc gttcccgact caatgccaca gcctcgttgg agcaggagag gagcgaaagg ccccgagcac ccggacccca ggctggccct ggccctggtg ttagagacgc agcggccccc gctgaacccc aggcccagca taccaggagc cgggaaagag cagacggcac cgggcctaca aagggagaca tggaaatccc ctttgaagaa gtcctggaga gggccaaggc cggggacccc aaggcacaga ctgaggtggg gaagcactac ctgcagttgg ccggcgacac ggatgaagaa ctcaacagct gcaccgctgt ggactggctg gtcctcgccg cgaagcaggg ccgtcgcgag gctgtgaagc tgcttcgccg gtgcttggcg gacagaagag gcatcacgtc cgagaacgaa cgggaggtga ggcagctctc ctccgagacc gacctggaga gggccgtgcg caaggcagcc ctggtcatgt actggaagct caaccccaag aagaagaagc aggtggccgt ggcggagctg ctggagaatg tcggccaggt caacgagcac gatggagggg cgcagccagg ccccgtgccc aagtccctgc agaagcagag gcgcatgctg gagcgcctgg tcagcagcga gtccaagaac tacatcgcgc tggatgactt tgtggagatc actaagaagt acgccaaggg cgtcatcccc agcagcctgt tcctgcagga cgacgaagat gatgacgagc tggcggggaa gagccctgag gacctgccac tgcgtctgaa ggtggtcaag taccccctgc acgccatcat ggagatcaag gagtacctga ttgacatggc ctccagggca ggcatgcact ggctgtccac catcatcccc acgcaccaca tcaacgcgct catcttcttc ttcatcgtca gcaacctcac catcgacttc ttcgccttct tcatcccgct ggtcatcttc tacctgtcct tcatctccat ggtgatctgc accctcaagg tgttccagga cagcaaggcc tgggagaact tccgcaccct caccgacctg ctgctgcgct tcgagcccaa cctggatgtg gagcaggccg aggtcaactt cggctggaac cacctggagc cctatgccca tttcctgctc tctgtcttct tcgtcatctt ctccttcccc atcgccagca aggactgcat cccctgctcg gagctggctg tcatcaccgg cttctttacc gtgaccagct acctgagcct gagcacccat gcagagccct acacgcgcag ggccctggcc accgaggtca ccgccggcct gctatcgctg ctgccctcca tgcccttgaa ttggccctac ctgaaggtcc ttggccagac cttcatcacc gtgcctgtcg gccacctggt cgtcctcaac gtcagcgtcc cgtgcctgct ctatgtctac ctgctctatc tcttcttccg catggcacag ctgaggaatt tcaagggcac ctactgctac cttgtgccct acctggtgtg cttcatgtgg tgtgagctct ccgtggtcat cctgctggag tccaccggcc tggggctgct ccgcgcctcc atcggctact tcctcttcct ctttgccctc cccatcctgg tggccggcct ggccctggtg ggcgtgctgc agttcgcccg gtggttcacg tctctggagc tcaccaagat cgcagtcacc gtggcggtct gtagtgtgcc cctgctgttg cgctggtgga ccaaggccag cttctctgtg gtggggatgg tgaagtccct gacgcggagc tccatggtca agctcatcct ggtgtggctc acggccatcg tgctgttctg ctggttctat gtgtaccgct cagagggcat gaaggtctac aactccacac tgacctggca gcagtatggt gcgctgtgcg ggccacgcgc ctggaaggag accaacatgg cgcgcaccca gatcctctgc agccacctgg agggccacag ggtcacgtgg accggccgct tcaagtacgt ccgcgtgact gacatcgaca acagcgccga gtctgccatc aacatgctcc cgttcttcat cggcgactgg atgcgctgcc tctacggcga ggcctaccct gcctgcagcc ctggcaacac ctccacggcc gaggaggagc tctgtcgcct taagctgctg gccaagcacc cctgccacat caagaagttc gaccgctaca agtttgagat taccgtgggc atgccattca gcagcggcgc tgacggctcg cgcagccgcg aggaggacga cgtcaccaag gacatcgtgc tgcgggccag cagcgagttc aagagcgtgc tgctcagcct gcgccagggc agcctcatcg agttcagcac catcctggag ggccgcctgg gcagcaagtg gcctgtcttc gagctcaagg ccatcagctg cctcaactgc atggcccagc tctcacccac caggcggcac gtgaagatcg agcacgactg gcgcagcacc gtgcatggcg ccgtgaagtt cgccttcgac ttctttttct tcccattcct gtcggcggcc tga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of WFS1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for WFS1. It may not necessarily be applicable to this product.
NCBI Accession #
BC030130
[Other Products]
UniProt Secondary Accession #
Q8N6I3; Q9UNW6; B2R797; D3DVT1[Other Products]
UniProt Related Accession #
O76024[Other Products]
Molecular Weight
100,292 Da
NCBI Official Full Name
Homo sapiens Wolfram syndrome 1 (wolframin), mRNA
NCBI Official Synonym Full Names
wolframin ER transmembrane glycoprotein
NCBI Official Symbol
WFS1??[Similar Products]
NCBI Official Synonym Symbols
WFS; WFRS; WFSL; CTRCT41
??[Similar Products]
NCBI Protein Information
wolframin
UniProt Protein Name
Wolframin
UniProt Gene Name
WFS1??[Similar Products]
UniProt Entry Name
WFS1_HUMAN
NCBI Summary for WFS1
This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for WFS1
WFS1: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 4p16.1
Cellular Component: dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane
Molecular Function: ATPase binding; protein binding; ubiquitin protein ligase binding
Biological Process: calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; ER overload response; ER-associated protein catabolic process; glucose homeostasis; kidney development; negative regulation of neuron apoptosis; negative regulation of programmed cell death; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; neurological system process; positive regulation of calcium ion transport; positive regulation of growth; positive regulation of protein metabolic process; positive regulation of protein ubiquitination; protein maturation via protein folding; protein stabilization; renal water homeostasis; sensory perception of sound; visual perception
Disease: Cataract 41; Deafness, Autosomal Dominant 6; Diabetes Mellitus, Noninsulin-dependent; Wolfram Syndrome 1; Wolfram-like Syndrome, Autosomal Dominant
Research Articles on WFS1
1. Data suggest that a novel mutation in WFS1 [c.13481350 del ins TAG (p.His450*)] causes Wolfram-like syndrome in homozygous daughter with maternal uniparental disomy of chromosome 4; heterozygous mother is unaffected. [CASE REPORT]
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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