Product Name
WFS1, Blocking Peptide
Full Product Name
WFS1 Blocking Peptide
Product Synonym Names
Wolframin
Product Gene Name
WFS1 blocking peptide
[Similar Products]
WFS1 peptide (MBS824049) is used for blocking the activity of WFS1 antibody (MBS822176)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O76024
Species Reactivity
Human, Mouse, Rat, Monkey
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of WFS1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
WFS1 blocking peptide
The peptide is used to block Anti-WFS1 Antibody reactivity.
Applications Tested/Suitable for WFS1 blocking peptide
Blocking (BL)
Application Notes for WFS1 blocking peptide
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
NCBI/Uniprot data below describe general gene information for WFS1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001139325.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001145853.1
[Other Products]
UniProt Primary Accession #
O76024
[Other Products]
UniProt Secondary Accession #
Q8N6I3; Q9UNW6; B2R797; D3DVT1[Other Products]
UniProt Related Accession #
O76024[Other Products]
Molecular Weight
100,292 Da
NCBI Official Full Name
wolframin
NCBI Official Synonym Full Names
Wolfram syndrome 1 (wolframin)
NCBI Official Symbol
WFS1??[Similar Products]
NCBI Official Synonym Symbols
WFS; WFRS; WFSL; CTRCT41
??[Similar Products]
NCBI Protein Information
wolframin
UniProt Protein Name
Wolframin
UniProt Gene Name
WFS1??[Similar Products]
UniProt Entry Name
WFS1_HUMAN
NCBI Summary for WFS1
This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for WFS1
WFS1: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 4p16.1
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; dendrite; integral to endoplasmic reticulum membrane
Molecular Function: calmodulin binding; transcription activator binding; transporter activity; ubiquitin protein ligase binding; calcium-dependent protein binding; ATPase binding
Biological Process: ER-associated protein catabolic process; protein maturation via protein folding; olfactory behavior; protein stabilization; positive regulation of proteolysis; unfolded protein response; negative regulation of transcription factor activity; glucose homeostasis; positive regulation of protein metabolic process; neurological system process; calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; sensory perception of sound; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; visual perception; positive regulation of protein ubiquitination; negative regulation of programmed cell death; renal water homeostasis; negative regulation of neuron apoptosis; kidney development; positive regulation of calcium ion transport; positive regulation of growth; ER overload response
Disease: Deafness, Autosomal Dominant 6; Wolfram Syndrome 1; Wolfram-like Syndrome, Autosomal Dominant; Cataract 41; Diabetes Mellitus, Noninsulin-dependent
Research Articles on WFS1
1. The decrease in wolframin expression in diabetic placenta suggests that this protein may participate in maintaining the physiologic glucose homeostasis in this organ.
Precautions
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Disclaimer
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