Rabbit Polyclonal (IgG) to Rat GJB1/CX32/Connexin 32; GJB1; Connexin 32; CMTX1; Connexin-32; CX32; Gap junction beta-1 protein; Gap junction protein beta-1; CMTX

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Connexin-32 antibody detects endogenous levels of Connexin-32.

Immunoaffinity Purified

PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol.

Store at -20 degree C.

Small volumes of anti-GJB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

GJB1/CX32/Connexin 32 is a member of the gap junction protein family. the gap junction proteins are membrane-spanning proteins thatassemble to form gap junction channels that facilitate the transfer ofions and small molecules between cells. According to sequencesimilarities at the nucleotide and amino acid levels, the gap junctionproteins are divided into two categories, alpha and beta. Mutations inthis gene cause X-linked Charcot-Marie-Tooth disease, an inheritedperipheral neuropathy.

Ion Channel; Connexin

ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

ELISA: 1:10000
IHC-P: 1:50
WB: 1:500-1:1000

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Western blot analysis of lysate from LOVO cells, using Connexin-32 antibody.

32,025 Da

gap junction protein beta 1

gap junction beta-1 protein

Gap junction beta-1 protein

CX32; Cx32??[Similar Products]

This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2008]

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

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