Product Name
HCRTR2, Polyclonal Antibody
Full Product Name
HCRTR2 Antibody
Product Synonym Names
hypocretin (orexin) receptor 2, OX2R
Product Gene Name
anti-HCRTR2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous level of total HCRTR2 protein.
Form/Format
Supplied at 2.3mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Immunogen Description
Synthetic peptide peptide corresponding to a region derived from 405-419 amino acids of human hypocretin (orexin) receptor 2
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-HCRTR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HCRTR2 antibody
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.
Product Categories/Family for anti-HCRTR2 antibody
Total protein Ab
Applications Tested/Suitable for anti-HCRTR2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-HCRTR2 antibody
ELISA: 1:2000-1:10000
Western blotting: 1:1000-1:5000
Testing Data of anti-HCRTR2 antibody
Gel: 10% SDS-PAGELane1: Mouse kidney tissue lysateLane2: Mouse brain tissue lysateLane3: Mouse heart tissue lysateLysates: 40ug per lanePrimary antibody: 1/1100 dilutionSecondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/5000 dilutionExposure time: 90 seconds
NCBI/Uniprot data below describe general gene information for HCRTR2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001517
[Other Products]
NCBI GenBank Nucleotide #
NM_001526.3
[Other Products]
UniProt Secondary Accession #
Q5VTM0[Other Products]
UniProt Related Accession #
O43614[Other Products]
Molecular Weight
50,694 Da
NCBI Official Full Name
orexin receptor type 2
NCBI Official Synonym Full Names
hypocretin (orexin) receptor 2
NCBI Official Symbol
HCRTR2??[Similar Products]
NCBI Official Synonym Symbols
OX2R
??[Similar Products]
NCBI Protein Information
orexin receptor type 2
UniProt Protein Name
Orexin receptor type 2
UniProt Synonym Protein Names
Hypocretin receptor type 2
Protein Family
Orexin receptor
UniProt Gene Name
HCRTR2??[Similar Products]
UniProt Synonym Gene Names
Ox-2-R; Ox2-R; Ox2R??[Similar Products]
UniProt Entry Name
OX2R_HUMAN
NCBI Summary for HCRTR2
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
UniProt Comments for HCRTR2
HCRTR2: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: neuropeptide receptor activity; orexin receptor activity; peptide hormone binding; peptide binding
Biological Process: synaptic transmission; neuropeptide signaling pathway; circadian sleep/wake cycle process; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of circadian sleep/wake cycle, sleep; cellular response to hormone stimulus
Research Articles on HCRTR2
1. The genotypic and allelic frequencies of the rs2653349 polymorphism were different between Alzheimer's disease patients and controls. The carriage of the G allele was associated with an increased AD risk.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
