Full Product Name
FOG2 Antibody
Product Gene Name
anti-FOG2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8WW38
Other Notes
Small volumes of anti-FOG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-FOG2 antibody
Western blot analysis FOG2 using Jurkat whole cell lysates
NCBI/Uniprot data below describe general gene information for FOG2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036214.2
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NCBI GenBank Nucleotide #
NM_012082.3
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UniProt Primary Accession #
Q8WW38
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UniProt Secondary Accession #
Q32MA6; Q9NPL7; Q9NPS4; Q9UNI5[Other Products]
UniProt Related Accession #
Q8WW38[Other Products]
Molecular Weight
113,229 Da
NCBI Official Full Name
zinc finger protein ZFPM2 isoform 1
NCBI Official Synonym Full Names
zinc finger protein, FOG family member 2
NCBI Official Symbol
ZFPM2??[Similar Products]
NCBI Official Synonym Symbols
DIH3; FOG2; SRXY9; ZNF89B; hFOG-2; ZC2HC11B
??[Similar Products]
NCBI Protein Information
zinc finger protein ZFPM2
UniProt Protein Name
Zinc finger protein ZFPM2
UniProt Synonym Protein Names
Friend of GATA protein 2; FOG-2; Friend of GATA 2; hFOG-2; Zinc finger protein 89B; Zinc finger protein multitype 2
UniProt Gene Name
ZFPM2??[Similar Products]
UniProt Synonym Gene Names
FOG2; ZNF89B; FOG-2; Friend of GATA 2; hFOG-2??[Similar Products]
NCBI Summary for FOG2
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]
UniProt Comments for FOG2
Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 ().
Research Articles on FOG2
1. when ZFPM2R698Q was co-transfected with GATA4, BNP promoter activity increased significantly, whereas co-transfection with ZFPM2R736L and GATA4 did not significantly increase BNP promoter activity. This suggests that the R698Q mutation may affect the ability of ZFPM2 to bind GATA4.
Precautions
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