Full Product Name
LCA5 Rabbit Polyclonal
Product Gene Name
anti-LCA5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Leber congenital amaurosis 5
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-LCA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LCA5 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for LCA5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001116241.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001122769.2
[Other Products]
UniProt Secondary Accession #
Q9BWX7; E1P542[Other Products]
UniProt Related Accession #
Q86VQ0[Other Products]
Molecular Weight
80,554 Da
NCBI Official Full Name
lebercilin
NCBI Official Synonym Full Names
LCA5, lebercilin
NCBI Official Symbol
LCA5??[Similar Products]
NCBI Official Synonym Symbols
C6orf152
??[Similar Products]
NCBI Protein Information
lebercilin
UniProt Protein Name
Lebercilin
UniProt Synonym Protein Names
Leber congenital amaurosis 5 protein
Protein Family
Lebercilin
UniProt Gene Name
LCA5??[Similar Products]
UniProt Synonym Gene Names
C6orf152??[Similar Products]
UniProt Entry Name
LCA5_HUMAN
NCBI Summary for LCA5
This gene encodes a protein that is thought to be involved in centrosomal or ciliary functions. Mutations in this gene cause Leber congenital amaurosis type V. Alternatively spliced transcript variants are described. [provided by RefSeq, Oct 2009]
UniProt Comments for LCA5
LCA5: Might be involved in minus end-directed microtubule transport. Defects in LCA5 are the cause of Leber congenital amaurosis type 5 (LCA5). LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children. Belongs to the LCA5 family.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 6q14.1
Cellular Component: cilium; cytoplasm; microtubule organizing center
Molecular Function: protein binding; protein complex binding
Biological Process: protein transport
Disease: Leber Congenital Amaurosis 5
Research Articles on LCA5
1. Identification of novel LCA5 mutations in patients with Leber congenital amaurosis and retinitis pigmentosa.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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